114671-83-9Relevant academic research and scientific papers
Total Synthesis of (-)-Mitrephorone A Enabled by Stereoselective Nitrile Oxide Cycloaddition and Tetrasubstituted Olefin Synthesis
Carreira, Erick M.,Richter, Matthieu J. R.,Schneider, Michael
, p. 17802 - 17809 (2020)
A highly enantioselective and diastereoselective total synthesis of the diterpenoid (-)-mitrephorone A is presented. Key to the synthesis are stereocontrolled 1,4-semihydrogenation of a 1,3-diene to a tetrasubstituted double bond, enzyme-catalyzed malonat
Chemoselective Alkylation for Diversity-Oriented Synthesis of 1,3,4-Benzotriazepin-2-ones and Pyrrolo[1,2][1,3,4]benzotriazepin-6-ones, Potential Turn Surrogates
Douchez, Antoine,Lubell, William D.
, p. 6046 - 6049 (2015)
1,3,4-Benzotriazepin-2-ones garner interest for medicinal applications, in part due to their relationship with benzodiazepinones. Ten 1,3,4-benzotriazepin-2-ones 6 and 19 and six pyrrolo[1,2][1,3,4]benzotriazepin-6-ones 7 and 23 were prepared in four to s
FE/CU-MEDIATED KETONE SYNTHESIS
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Paragraph 00205; 00207, (2019/01/22)
Provided herein are methods for preparing ketone-containing organic molecules. The methods are based on novel iron/copper-mediated ("Fe/Cu-mediated") coupling reactions. The Fe/Cu-mediated coupling reaction can be used in the preparation of complex molecu
NiH-Catalyzed Reductive Relay Hydroalkylation: A Strategy for the Remote C(sp3)?H Alkylation of Alkenes
Zhou, Fang,Zhu, Jin,Zhang, Yao,Zhu, Shaolin
, p. 4058 - 4062 (2018/03/21)
The terminal-selective, remote C(sp3)?H alkylation of alkenes was achieved by a relay process combining NiH-catalyzed hydrometalation, chain walking, and alkylation. This method enables the construction of unfunctionalized C(sp3)?C(sp3) bonds under mild conditions from two simple feedstock chemicals, namely olefins and alkyl halides. The practical value of this transformation is further demonstrated by the large-scale and regioconvergent alkylation of isomeric mixtures of olefins at low catalyst loadings.
Fe/Cu-Mediated One-Pot Ketone Synthesis
Kumar, Vemula Praveen,Babu, Vaddela Sudheer,Yahata, Kenzo,Kishi, Yoshito
supporting information, p. 2766 - 2769 (2017/05/24)
An Fe/Cu-mediated one-pot ketone synthesis was reported. Unlike Ni- and Pd-mediated one-pot ketone syntheses, the reported Fe/Cu-mediated method allowed selective activation and coupling of alkyl iodides over vinyl iodides. The newly developed one-pot ket
Synthetic studies on the nhatrangins: Stereoselective access to an advanced aldehyde intermediate
Raffier, Ludovic,Piva, Olivier
, p. 1124 - 1131 (2013/03/28)
Two different strategies have been considered to achieve the first total synthesis of nhatrangins A and B. The first approach based on a cross metathesis (CM) reaction was unsuccessful. The second, which combined a highly stereoselective alkylation, a diastereoselective aldolization, and finally an esterification, furnished an advanced aldehyde intermediate bearing the three contiguous stereogenic centres and the expected side-chain. Two strategies have been considered for the stereoselective synthesis of nhatrangins A and B. A sequence involving diastereoselective alkylation and aldolization employing ephedrine derivatives as chiral auxiliaries was the most efficient approach to deliver a key aldehyde framework. Copyright
Cyclopentanone derivatives, method of synthesis and uses thereof
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Page/Page column 20, (2008/12/06)
The present invention relates to cyclopentanone derivatives of formula (I), their method of synthesis and uses thereof. Concretely, the compounds disclosed have proved to be inhibitors of glycogen synthase kinase 3β, GSK-3 β, which is known to be involved in different disease and conditions, such as Alzheimer's disease or non-insulin dependent diabetes mellitus. The present invention also relates to pharmaceutical compositions comprising the same. Further, the present invention is directed to the use of the compounds in the manufacture of a medicament for the treatment and/or prevention of a GSK-3 mediated disease or condition.
SYNTHESIS OF CHLORINS AND PHORBINES WITH ENHANCED RED SPECTRAL FEATURES
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Page/Page column 124-125; 136, (2008/06/13)
The present invention provides compounds of the general Formula DI: along with methods of making such compounds, formulations containing the same, and methods of using the same (e.g., in photodynamic therapy, for the production of solar cells, etc.).
Enantioselective synthesis of a hindered furyl substituted allyl alcohol intermediate: A case study in asymmetric synthesis
Pihko, Ainoliisa J.,Lundell, Katri,Kanerva, Liisa,Koskinen, Ari M.P.
, p. 1637 - 1643 (2007/10/03)
In the course of the synthesis of the DEFG ring system of cneorin C 1, we were faced with the task of preparing the furyl substituted allyl alcohol 5 enantioselectively. Several different methods starting from enantioselective zinc-mediated alkylations were attempted, but none of them proved entirely satisfactory. The solution turned out to be enzymatic kinetic resolution through a highly enantioselective (E>300) acylation in the presence of Candida antarctica lipase A.
The furan approach to oxacycles: Synthesis of medium-size 2,3-disubstituted oxacycles
Pérez, Manuel,Canoa, Pilar,Gómez, Generosa,Terán, Carmen,Fall, Yagamare
, p. 5207 - 5209 (2007/10/03)
We describe an efficient new approach for the synthesis of medium-size oxacycles that is based on the oxidation of a furan ring with singlet oxygen followed by an intramolecular Michael addition. This present study enlarges the scope of the furan approach strategy for the synthesis of oxepanes.
