199010-29-2Relevant articles and documents
Synthesis, structure and catecholase activity study of dinuclear copper(II) complexes
Reim, Joerg,Krebs, Bernt
, p. 3793 - 3804 (1997)
A series of dinuclear copper(II) complexes as models for the type 3 copper protein catechol oxidase were synthesised. They were characterised by spectroscopic, electrochemical, and in some cases, by single-crystal X-ray diffraction studies: [Cu2(L1)(OH)(EtOH)(H2O)][ClO4] 2·H2O 1, [Cu2(L2)(OH)][NO3]2 2, [Cu2(L3)(OMe)(MeOH)-(ClO4)]ClO4 3, [Cu2(L4)(OH)(MeOH)2][BF4] 2 4, [Cu2(L5)(OMe)][ClO4]2·2MeOH 5, [Cu2(L6)(OMe)(MeOH)-(ClO4)]ClO4 6 and [Cu2(L7)(OMe)(MeOH)(ClO4)]ClO4 7 (HL1 = 4-bromo-2,6-bis(4-methylpiperazin-1-ylmethyl)-phenol, HL2 = 4-bromo-2,6-bis[(2-pyridylmethyl)aminomethyl]phenol, HL3 = 4-bromo-2,6-bis{[2-(2-pyridyl)-ethyl]aminomethyl}phenol, HL4 = 4-bromo-2,6-bis{[2-(1-methyl-2-imidazolyl)ethyl]aminomethyl}phenol, HL5 = 4-bromo-2-(4-methylpiperazin-1-ylmethyl)-6-[(2-pyridylmethyl)aminomethyl]phenol, HL6 = 4-bromo-2-(4-methylpiperazin-1-ylmethyl)-6-{[2-(2-pyridyl)ethyl]aminomethyl} phenol and HL7 = 4-bromo-2-(4-methyl-piperazin-1-ylmethyl)-6-{[2-(1-methyl-2-imidazolyl)ethyl] aminomethyl}phenol). The copper centres are μ-phenoxo bridged by the pentadentate dinucleating ligand and exogenously μ-hydroxo or μ-methanolato bridged. Complex 1 crystallises in P21/c with a = 16.913(3), b = 11.046(2), c = 16.617(3) A, β = 94.06(3)°, U = 3097 A3 and Z = 4. Complex 3 crystallises in P21/n with a = 10.592(2), b = 12.123(2), c = 24.482(5) A, β = 92.97(3)°, U = 3139 A3 and Z = 4. Complex 4 crystallises in Pbcn with a = 16.043(3), b = 12.689(3), c = 15.810(3) A, U = 3218 A3 and Z = 4. Complex 6 crystallises in P21/c with a = 17.889(4), b = 10.401(2), c = 16.269(4) A, β = 92.94(2)°, U = 3023 A3 and Z = 4. Complex 7 crystallises in P21/c with a = 17.349(3), b = 8.828(2), c = 19.797(4) A, β = 94.04(3)°, U = 3025 A3 and Z = 4. A catecholase activity study revealed that only complexes 1, 5, 6 and 7 have significant catalytic activity with respect to the aerial oxidation of 3,5-di-tert-butylcatechol. A kinetic treatment on the basis of the Michaelis-Menten model was applied.
