109517-99-9Relevant articles and documents
Two-component assembly of recognition-encoded oligomers that form stable H-bonded duplexes
Gabrielli, Luca,Nú?ez-Villanueva, Diego,Hunter, Christopher A.
, p. 561 - 566 (2020)
A new family of recognition-encoded oligomers that form stable duplexes in chloroform have been prepared. Monomer building blocks composed of dialdehydes functionalised with either a trifluoromethylphenol or phosphine oxide H-bond recognition unit were prepared. The dialdehydes were coupled with diamines by imine formation and then reduction to give homo-oligomers between one and three recognition units in length. Duplex formation was characterised by 19F and 1H NMR titration experiments in toluene and in chloroform. For duplexes formed between length complementary H-bond donor and acceptor homo-oligomers, an order of magnitude increase in stability was observed for every base-pair added to the duplex in chloroform. The effective molarity for the intramolecular H-bonds responsible for zipping up the duplex is 30 mM, which results in the fully assembled duplex in all cases. The uniform increase in duplex stability with oligomer length suggests that the backbone structure and geometry is likely to be compatible with the formation of extended duplexes in longer oligomers.
Bimetallic Bis-anion Cascade Complexes of Magnesium in Nonaqueous Solution
Carta, Veronica,Flood, Amar H.,Flynn, Ian G.,Van Craen, David
, (2020)
Bimetallic magnesium(II) complexes are gaining significant interest in catalysis, yet their fundamental formation and behavior in organic media remain surprisingly unexplored relative to other divalent cations. To understand key principles of their formation, we investigate symmetric ditopic ligands bearing a phenolic backbone and characterize their ability to form dinuclear magnesium(II) cascade complexes with two bridging anions. High-fidelity production of bimetallic magnesium complexes relative to the monometallic complexes is indicative of positive cooperativity. Binding and recognition of analytes or substrates is a key characteristic of metal cascade complexes and relies on anion exchange, but this is also rarely studied with bimetallic magnesium complexes. Investigations with acetate, phosphate, and pyrophosphate reveal exchange of bridging nitrates using the bis-dipicolylamine complex. Rare seven-coordinate magnesium centers are found for the ester complex. The findings in this study provide formative steps to establish design principles for future generations of bimetallic magnesium(II) complexes.
One-pot Synthesis of a Truncated Cone-shaped Porphyrin Macrocycle and Its Self-assembly into Permanent Porous Material
Kim, Ikjin,Dhamija, Avinash,Hwang, In-Chul,Lee, Hochan,Ko, Young Ho,Kim, Kimoon
, p. 3209 - 3212 (2021)
Here, we report the synthesis of a truncated cone-shaped triangular porphyrinic macrocycle, P3L3, via a single step imine condensation of a cis-diaminophenylporphyrin and a bent dialdehyde-based linker as building units. X-ray diffra
A simple but highly efficient multi-formyl phenol-amine system for fluorescence detection of peroxide explosive vapour
Xu, Wei,Fu, Yanyan,Gao, Yixun,Yao, Junjun,Fan, Tianchi,Zhu, Defeng,He, Qingguo,Cao, Huimin,Cheng, Jiangong
, p. 10868 - 10870 (2015)
A simple, highly stable, sensitive and selective fluorescent system for peroxide explosives was developed via an aromatic aldehyde oxidation reaction. The high efficiency arises from its higher HOMO level and multiple H-bonding. The sensitivity is obtaine
Carboxylic Acid Functionalized Clathrochelate Complexes: Large, Robust, and Easy-to-Access Metalloligands
Marmier, Mathieu,Wise, Matthew D.,Holstein, Julian J.,Pattison, Philip,Schenk, Kurt,Solari, Euro,Scopelliti, Rosario,Severin, Kay
, p. 4006 - 4015 (2016)
Polycarboxylate ligands are among the most important building blocks for the synthesis of metal-organic frameworks (MOFs). The ability to access these ligands in an efficient way is of key importance for future applications of MOFs. Here, we demonstrate that mono- and dinuclear clathrochelate complexes are versatile scaffolds for the preparation of polytopic carboxylate ligands. The largely inert clathrochelate complexes have a trigonal-bipyramidal shape. The synthesis of functionalized clathrochelates with two, three, four, or five carboxylic acid groups in the ligand periphery can be achieved in a few steps from simple starting materials. Apart from being easily accessible, the metalloligands display interesting characteristics for applications in metallasupramolecular chemistry and materials science: they are rigid, large (up to 2.2 nm), and robust and they can show additional functions (e.g., fluorescence or extra charge) depending on the metal ion that is present in the clathrochelate core. The utility of these new metalloligands in MOF chemistry is demonstrated by the synthesis of zinc- and zirconium-based coordination polymers. The combination of Zn(NO3)2 with clathrochelates having two or three carboxylic acid groups gives MOFs in which the clathrochelate ligands are connected by Zn4O clusters or zinc paddlewheel links. The structures of the resulting two- and three-dimensional networks could be established by single-crystal X-ray crystallography. The reaction of carboxylic acid functionalized clathrochelates with ZrCl4 gives amorphous powders that display permanent porosity after solvent removal.
Multi-group compound with fluorescence specific response to different anions as well as preparation method and application of multi-group compound
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Paragraph 0017-0023, (2021/05/12)
The invention discloses a multi-group compound with fluorescence specific response to different anions as well as a preparation method and application thereof, and relates to the field of compounds. The multi-group compound has a structure shown in the sp
Preparation method of a special impurity of febuxostat
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Paragraph 0024; 0025; 0026; 0030; 0031; 0035; 0036, (2020/01/12)
The invention provides a preparation method of a special impurity of febuxostat. The preparation method is as follows: (1): first, two aldehyde groups are introduced on a benzene ring through a reaction of N1 and HMTA to form N2, and the yield is up to 90% due to reduction of steric resistance; (2): a coupling reaction of N2 and N3 is carried out to produce A, and the yield is up to 70%; (3): A reacts with hydroxylamine hydrochloride to form B, and the yield is about 80%; and (4): B is subjected to hydrolysis to obtain C, and the yield is about 90%. According to the preparation method of the specific impurity of febuxostat, the total yield of synthesizing C is about 45%. Compared with the prior art, the yield is greatly improved, and the starting raw materials N1 and N3 of the new synthetic route are cheap and easy to obtain, the method is suitable for large-scale synthesis, and the disadvantages that amount accumulation and purification are relatively difficult when A is synthesized from M3 in the prior art are avoided.
