19906-72-0 Usage
Description
Bakkenolide A, a natural product derived from the plant Petasites tricholobus, is a sesquiterpene lactone with a unique chemical structure. It exhibits various biological activities, such as anti-inflammatory and anti-tumor properties, making it a promising candidate for the development of novel pharmaceutical agents.
Uses
Used in Pharmaceutical Industry:
Bakkenolide A is used as an anti-inflammatory agent for its ability to inhibit the production of inflammatory mediators, such as nitric oxide and prostaglandins. This property makes it a potential therapeutic agent for treating inflammatory conditions.
Used in Oncology:
Bakkenolide A is used as an anti-tumor agent due to its potent cytotoxic effects against cancer cells. Its potential therapeutic applications in oncology make it a promising candidate for the development of novel cancer treatments.
Used in Drug Discovery and Development:
The discovery of bakkenolide A highlights the importance of natural products in drug discovery and development. Its unique chemical structure and biological activities make it a valuable resource for identifying new therapeutic agents and expanding the scope of pharmaceutical research.
Check Digit Verification of cas no
The CAS Registry Mumber 19906-72-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,9,9,0 and 6 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 19906-72:
(7*1)+(6*9)+(5*9)+(4*0)+(3*6)+(2*7)+(1*2)=140
140 % 10 = 0
So 19906-72-0 is a valid CAS Registry Number.
InChI:InChI=1/C15H22O2/c1-10-5-4-6-12-7-15(9-14(10,12)3)11(2)8-17-13(15)16/h10,12H,2,4-9H2,1,3H3/t10-,12+,14+,15+/m0/s1
19906-72-0Relevant articles and documents
Conversion of optically active hydrindanone to (+)-bakkenolide-A
Kusakabe, Taichi,Kato, Keisuke,Motodate, Satoshi,Takaishi, Satoshi,Akita, Hiroyuki
, p. 1436 - 1437 (2008)
A total synthesis of (+)-bakkenolide-A was carried out via the key intermediate 4, which was prepared based on an asymmetric cyclization- carbonylation reaction established in our laboratory. Diastereoselective construction of the spirolactone moiety was achieved using Mitsuhashi's protocol as a key step.
Synthesis of bakkenolide A
Hayashi,Nakamura,Mitsuhashi
, p. 2806 - 2807 (1973)
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Core structure of eremophilanes and bakkanes through niobium catalyzed Diels-Alder reaction: Synthesis of (±)-bakkenolide A
Constantino, Mauricio G.,De Oliveira, Kleber T.,Polo, Ellen C.,Da Silva, Gil V. J.,Brocksom, Timothy J.
, p. 9880 - 9883 (2007/10/03)
A suitable intermediate for the synthesis of eremophilanes and bakkanes was prepared by a highly regioselective and stereoselective one-step synthesis through a niobium catalyzed Diels-Alder reaction. As a demonstration of the versatility of this intermed
