19908-69-1Relevant articles and documents
Enantioselective Conjugate Addition Greatly Improves the Synthesis of (+)-Confertin
Quinkert, Gerhard,Mueller, Thomas,Koeniger, Andreas,Schultheis, Oliver,Sickenberger, Birgitt,Duerner, Gerd
, p. 3469 - 3472 (1992)
The five-membered ring building blocks 2+3 are enantioselectively produced by conjugate addition of a chiral ligand-modified organocuprate to 2-methylcyclopent-2-enone (1) (chemical yield: 88percent; e.e.: 88percent) and successfully converted in a multi-step sequence, after final enantioselection by recrystallization of an appropriate intermediate, into the pseudoguaianolide (+)-confertin (5).- Key Words: enantioselective conjugate addition; chiral ligand-modified organocuprates; total synthesis of (+)-confertin
Allylsilane-Based Annulations. Direct Stereoselective Syntheses of (+/-)-Graveolide and (+/-)-Aromaticin
Majetich, George,Song, Jee-Seop,Leigh, Alistair J.,Condon, Stephen M.
, p. 1030 - 1037 (2007/10/02)
An allylsilane-based annulation was used to construct a functionalized perhydroazulene.The C(1), C(5), and C(10) stereocenters, characteristic of the helenanolides, were established using a reductive alkylation strategy.Stereoselective syntheses of the pseudoguaianolides graveolide and aromaticin were achieved.
Totalsynthese des Pseudoguaianolids (+)-Confertin
Quinkert, Gerhard,Schmalz, Hans-Guenther,Walzer, Egon,Kowalczyk-Przewloka, Teresa,Duerner, Gerd,Bats, Jan W.
, p. 82 - 84 (2007/10/02)
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