199103-91-8Relevant academic research and scientific papers
Serine derivatives and their use as therapeutic agents
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, (2008/06/13)
The present invention relates to compounds of formula (I): STR1 wherein m is zero, 1 or 2; and n is zero or 1, with the proviso that the sum total of m+n is 1 or 2; R1 represents phenyl; naphthyl; benzhydryl; or benzyl, where the naphthyl group or any phenyl moiety may be substituted; R2 represents hydrogen; phenyl; heteroaryl selected from indazolyl, thienyl, furanyl, pyridyl, thiazolyl, tetrazolyl and quinolinyl; naphthyl; benzhydryl; or benzyl; wherein each heteroaryl, the naphthyl group and any phenyl moiety may be substituted; R3 and R4 each independently represents hydrogen or C1-6 alkyl or R3 and R4 together are linked so as to form a C1-3 alkylene chain; Q represents CR5 R6 or NR5 ; X and Y each independently represents hydrogen, or together form a group =O; and Z represents a bond, O, S, SO, SO2, NRc or --(CRc Rd)--, where Rc and Rd each independently represent hydrogen or C1-6 alkyl; or a pharmaceutically acceptable salt thereof. The compounds are of particular use in the treatment or prevention of pain, inflammation, migraine, emesis and postherpetic neuralgia.
