199105-03-8

Basic information

• Product Name: 4-(2-AMINO-PHENYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
• Synonyms: TERT-BUTYL 4-(2-AMINOPHENYL)PIPERIDINE-1-CARBOXYLATE;N-BOC-4(2-AMINOPHENYL) PIPERIDINE;4-(2-AMINO-PHENYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;4-(o-AMino-phenyl)-1-N-Boc piperidine;4-(2-Aminophenyl)-1-piperidinecarboxylic acid tert-butyl ester
• CAS NO: 199105-03-8
• Molecular Formula: C₁₆H₂₄N₂O₂
• Molecular Weight: 276.37
• Product Categories: pharmacetical
• Mol File: 199105-03-8.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 391℃
• Flash Point: 191℃
• Appearance: /
• Density: 1.100
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-(2-AMINO-PHENYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-AMINO-PHENYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(199105-03-8)
• EPA Substance Registry System: 4-(2-AMINO-PHENYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(199105-03-8)

Safety Data

• Hazardous Substances Data: 199105-03-8(Hazardous Substances Data)

Usage

General Description

The chemical 4-(2-amino-phenyl)-piperidine-1-carboxylic acid tert-butyl ester is a compound with the molecular formula C17H24N2O2. It is a tert-butyl ester derivative of piperidine-1-carboxylic acid, a piperidine derivative containing an amino-phenyl group. 4-(2-AMINO-PHENYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER has potential applications in medicinal chemistry and drug development due to the presence of the piperidine and amino-phenyl moieties, which are common structural elements in many bioactive compounds. Its tert-butyl ester functional group also makes it a versatile building block for the synthesis of other chemical compounds. Overall, this chemical has potential uses in academic research and industrial applications in the pharmaceutical and fine chemical industries.

Upstream product

• 577-19-5 2-nitrophenyl bromide 
• 375853-82-0 tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-1(2H)-pyridinecarboxylate 
• 955397-70-3 4-(2-aminophenyl)-5,6-dihydropyridine-1(2H)-carboxylic acid tert-butyl ester 
• 494795-55-0 tert-butyl 4-(2-nitrophenyl)-5,6-dihydropyridine-1(2H)-carboxylate 
• 199105-02-7 4-(2-tert-Butoxycarbonylamino-phenyl)-piperidine-1-carboxylic acid tert-butyl ester 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 115377-94-1 2-(tert-butoxycarbonylamino)phenylboronic acid 
• 24424-99-5 di-tert-butyl dicarbonate 
• 255050-94-3 4-(2-aminophenyl)piperidine 

Downstream Products

• 255051-00-4 4-[2-(3-Methylureido)phenyl]-N-Boc-piperidine 
• 494795-92-5 tert-Butyl 4-(2-{[(2,2-dimethoxyethyl)methylamino]carbonylamino}-phenyl)piperidinecarboxylate 
• 255051-02-6 tert-butyl 4-(2-(dimethylamino)phenyl)piperidine-1-carboxylate 
• 255051-52-6 methyl 3-[N-(2-{1-[tert-butyloxycarbonyl]-4-piperidyl}phenyl)carbamoyl]propanoate 
• 255050-96-5 4-(2-Acetamidophenyl)-N-Boc-piperidine 
• 494795-99-2 tert-butyl 4-{2-[(fluoren-9-ylmethoxy)carbonylamino]phenyl}piperidine-carboxylate 
• 199105-07-2 4-[2-(Methanesulfonyl-methyl-amino)-phenyl]-piperidine-1-carboxylic acid tert-butyl ester 
• 199105-08-3 N-Methyl-N-(2-piperidin-4-yl-phenyl)-methanesulfonamide 
• 199105-05-0 4-{2-[(Methylsulfonyl)amino]phenyl}-piperidine 
• 199105-04-9 tert-Butyl 4-{2-[(methylsulfonyl)amino]phenyl}piperidinecarboxylate 

Relevant articles and documents

N-(PHENYL)-2-(PHENYL)PYRIMIDINE-4-CARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS HPK1 INHIBITORS FOR TREATING CANCER

The present invention relates to N-(phenyl)-2-(phenyl)pyrimidine-4- carboxamide derivatives and related compounds of formula I as HPK1 (Hematopoietic progenitor kinase 1) inhibitors for treating cancer, such as e.g. breast cancer, colorectal cancer, lung cancer, ovarian cancer, and pancreatic cancer. Preferred compounds are e.g. N-(5-Fluoro-2-(2-(pyridin-2-yl)pyrrolidin-l-yl)phenyl)-2-(2- fluoro-6-methoxyphenyl)pyrimidine-4-carboxamide and N-(5-Fluoro-2- (hexahydropyrrolo[3,4-b]pyrrol-l(2H)-yl)phenyl)-2-(2-fluoro-6- methoxyphenyl)pyrimidine-4-carboxamide.

SMALL MOLECULE AGONISTS OF NEUROTENSIN RECEPTOR 1

Provided herein are small molecule neurotensin receptor agonists, compositions comprising the compounds, and methods of using the compounds and compositions comprising the compounds.

Substituted piperidines and methods of use

Selected substituted piperidine compounds are effective for prophylaxis and treatment of diseases, such as obesity and the like. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving activation of the melanocortin receptor. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.