199105-19-6

Basic information

• Product Name: N-[2-(PIPERAZIN-1-YL)PHENYL]METHYLSULPHONAMIDE HYDROCHLORIDE
• Synonyms: N-[2-(PIPERAZIN-1-YL)PHENYL]METHYLSULPHONAMIDE HYDROCHLORIDE;N-(2-(piperazin-1-yl)phenyl)methanesulfonamide hydrochloride
• CAS NO: 199105-19-6
• Molecular Formula: C₁₁H₁₇N₃O₂S
• Molecular Weight: 291.801
• Mol File: 199105-19-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 452.5°C at 760 mmHg
• Flash Point: 227.5°C
• Appearance: /
• Density: 1.288±0.06 g/cm3(Predicted)
• Vapor Pressure: 1.36E-08mmHg at 25°C
• PKA: 10.02±0.10(Predicted)
• CAS DataBase Reference: N-[2-(PIPERAZIN-1-YL)PHENYL]METHYLSULPHONAMIDE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-[2-(PIPERAZIN-1-YL)PHENYL]METHYLSULPHONAMIDE HYDROCHLORIDE(199105-19-6)
• EPA Substance Registry System: N-[2-(PIPERAZIN-1-YL)PHENYL]METHYLSULPHONAMIDE HYDROCHLORIDE(199105-19-6)

Safety Data

• Hazardous Substances Data: 199105-19-6(Hazardous Substances Data)

Usage

General Description

N-[2-(piperazin-1-yl)phenyl]methanesulfonamide hydrochloride is a chemical compound with the molecular formula C12H19N3O2S?HCl. It is a sulfonamide derivative with a piperazine group, commonly used as an anti-bacterial and anti-inflammatory agent. N-[2-(PIPERAZIN-1-YL)PHENYL]METHYLSULPHONAMIDE HYDROCHLORIDE is known to have antibacterial properties and is used in the treatment of various infections. It acts by inhibiting the synthesis of folic acid in bacteria, ultimately leading to their death. Additionally, it has also shown potential in the treatment of certain inflammatory conditions. N-[2-(piperazin-1-yl)phenyl]methanesulfonamide hydrochloride is commonly used in pharmaceutical formulations and medical research.

InChI:InChI=1/C11H17N3O2S.ClH/c1-17(15,16)13-10-4-2-3-5-11(10)14-8-6-12-7-9-14;/h2-5,12-13H,6-9H2,1H3;1H

Upstream product

• 37073-18-0 N-(2-aminophenyl)methanesulfonamide 
• 25024-96-8 C₁₁H₁₇N₃O₂S*ClH 
• 199105-17-4 2-(4-benzylpiperazin-1-yl)aniline 
• 59084-06-9 1-(2-nitrophenyl)piperazine 
• 170017-74-0 1-[1,1-dimethylethoxycarbonyl]-4-(2-aminophenyl)piperazine 
• 170017-73-9 1-[1,1-Dimethylethoxycarbonyl]-4-(2-nitrophenyl)piperazine 
• 88-73-3 2-Chloronitrobenzene 
• 444582-15-4 1-tert-butoxycarbonyl-4-(2-((methylsulfonyl)amino)phenyl)piperazine 
• 199105-18-5 N-[2-(4-Benzyl-piperazin-1-yl)-phenyl]-methanesulfonamide 
• 199105-16-3 1-benzyl-4-(2-nitrophenyl)piperazine 

Downstream Products

• 1579960-78-3 N-(2-(4-(3-(2-(4-bromophenoxy)ethoxy)-2-hydroxypropyl)piperazin-1-yl)phenyl)methanoesulfonamide 

Relevant articles and documents

Synthesis and evaluation of a novel class Hsp90 inhibitors containing 1-phenylpiperazine scaffold

Previously, we identified 1-(2-(4-bromophenoxy)ethoxy)-3-(4-(2- methoxyphenyl)piperazin-1-yl)propan-2-ol (1) as a novel Hsp90 inhibitor with moderate activity through virtual screening. In this study, we report the optimization process of 1. A series of analogues containing the 1-phenylpiperazine core scaffold were synthesized and evaluated. The structure-activity relationships (SAR) for these compounds was also discussed for further molecular design. This effort afforded the most active inhibitor 13f with improved activity in not only target-based level, but also cell-based level compared with the original hit 1.

Serine derived NK1 antagonists 2: A pharmacophore model for arylsulfonamide binding

Modifications to the spirocyclic aryl sulfonamide portion of serine derived NK1 antagonists allow a partial pharmacophore model to be developed.