199114-40-4

Basic information

• Product Name: 4-[2-[2-ethyl-4-methyl-6-oxo-1,6-dihydropyrimidin-1-yl]ethoxy]benzaldehyde oxime
• Synonyms: 4-[2-[2-ethyl-4-methyl-6-oxo-1,6-dihydropyrimidin-1-yl]ethoxy]benzaldehyde oxime
• CAS NO: 199114-40-4
• Molecular Weight: 301.345
• Mol File: 199114-40-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-[2-[2-ethyl-4-methyl-6-oxo-1,6-dihydropyrimidin-1-yl]ethoxy]benzaldehyde oxime(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[2-[2-ethyl-4-methyl-6-oxo-1,6-dihydropyrimidin-1-yl]ethoxy]benzaldehyde oxime(199114-40-4)
• EPA Substance Registry System: 4-[2-[2-ethyl-4-methyl-6-oxo-1,6-dihydropyrimidin-1-yl]ethoxy]benzaldehyde oxime(199114-40-4)

Safety Data

• Hazardous Substances Data: 199114-40-4(Hazardous Substances Data)

Upstream product

• 52191-15-8 4-(2-bromoethyloxy)benzaldehyde 
• 16858-50-7 2-ethyl-6-methyl-4(3H)pyrimidone 
• 199114-26-6 4-[2-[2-ethyl-4-methyl-6-oxo-1,6-dihydropyrimidin-1-yl]ethoxy]benzaldehyde 

Downstream Products

• 199114-42-6 N-{4-[2-[2-ethyl-4-methyl-6-oxo-1,6-dihydropyrimidin-1-yl]ethoxy]benzyl}-N-hydroxyurea 
• 199114-41-5 4-[2-[2-ethyl-4-methyl-6-oxo-1,6-dihydropyrimidin-1-yl]ethoxy]benzyl hydroxyl amine 

Relevant articles and documents

Synthesis and biological activity of novel pyrimidinone containing thiazolidinedione derivatives

A series of pyrimidinone derivatives of thiazolidinediones were synthesized. Their biological activity were evaluated in insulin resistant, hyperglycemic and obese db/db mice. In vitro PPARγ transactivation assay was performed in HEK 293T cells. PMT13 showed the best biological activity in this series. PMT13 (5-[4-[2-[2-ethyl-4-methyl-6-oxo-1,6-dihydro-1-pyrimidinyl]ethoxy] phenylmethyl]thiazolidine-2,4-dione) showed better plasma glucose, triglyceride and insulin-lowering activity in db/db mice than rosiglitazone and pioglitazone. PMT13 showed better PPARγ transactivation than the standard compounds. Pharmacokinetic study in Wistar rats showed good systemic exposure of PMT13. Twenty-eight day oral toxicity study in Wistar rats did not show any treatment-related adverse effects.