16858-50-7

Upstream product

• 141-97-9 ethyl acetoacetate 
• 3599-89-1 propionamidine hydrochloride 
• 64163-94-6 β-aminocrotonamide 
• 107-12-0 propiononitrile 

Downstream Products

• 75074-97-4 2-ethyl-4-methyl-pyrimidine 
• 199114-26-6 4-[2-[2-ethyl-4-methyl-6-oxo-1,6-dihydropyrimidin-1-yl]ethoxy]benzaldehyde 
• 1201793-19-2 N-(4,5-dimethyl-3-isoxazolyl)-4'-[[(6-methyl-2-ethyl-4-pyrimidinyl)oxy]methyl]-2'-(ethoxymethyl)[1,1'-biphenyl]-2-sulfonamide 
• 199114-24-4 4-[2-[4-methyl-2-propyl-6-oxo-1,6-dihydropyrimidin-1-yl]ethoxy]benzaldehyde 
• 199114-53-9 5-[4-[2-[2-ethyl-4-methyl-6-oxo-1,6-dihydropyrimidin-1-yl]ethoxy]phenylmethylene]-2-thioxo-1,3-oxazolidine-4-one 
• 199113-79-6 5-[4-[2-[2-ethyl-4-methyl-6-oxo-1,6-dihydropyrimidin-1-yl]ethoxy]phenylmethylene]thiazolidine-2,4-dione 
• 199113-95-6 PMT₁₃ 
• 199114-42-6 N-{4-[2-[2-ethyl-4-methyl-6-oxo-1,6-dihydropyrimidin-1-yl]ethoxy]benzyl}-N-hydroxyurea 
• 199114-41-5 4-[2-[2-ethyl-4-methyl-6-oxo-1,6-dihydropyrimidin-1-yl]ethoxy]benzyl hydroxyl amine 
• 199114-40-4 4-[2-[2-ethyl-4-methyl-6-oxo-1,6-dihydropyrimidin-1-yl]ethoxy]benzaldehyde oxime 

Relevant academic research and scientific papers

Ultrasound-Promoted Synthesis of 4-Pyrimidinols and Their Tosyl Derivatives

Ultrasound irradiation promoted the cyclocondensation of β-keto esters and amidines in good to excellent yields to form sixteen highly substituted 4-pyrimidinols. Tosylation of these compounds, in another ultrasound-promoted conversion, formed 4-pyrimidyl tosylates in high yields. The use of the developed protocol as an alternative route to 4-arylpyrimidines was illustrated with three examples of the Suzuki-Miyaura cross-coupling of the prepared tosylates with phenylboronic acid.

REACTION OF 3-AMINOCROTONAMIDE WITH NITRILES

The reaction of 3-aminocrotonamide (5) with some nitriles, such as acetonitrile, propiononitrile, iso-butyronitrile, and benzonitrile, gave the corresponding 2-substituted 6-methyl-4(3H)-pyrimidones (2a-2d).Phenylacetonitrile reacted with (5) to give 2-benzyl-6-methyl-4(3H)-pyrimidone (7) and 6-amino-4-methyl-5-phenyl-2(1H)-pyridone (8a).Malononitrile, however, reacted with (5) to afford 6-amino-5-cyano-4-methyl-2(1H)-pyridone (8b).