19916-72-4

Usage

Uses

Used in Coordination Chemistry:
2,4,5-Pyrimidinetriamine, 6-(phenylmethoxy)is used as a ligand for [coordination with metal ions] for [forming stable complexes and studying their properties].
Used in Catalysis:
2,4,5-Pyrimidinetriamine, 6-(phenylmethoxy)is used as a catalyst for [enhancing the rate of chemical reactions] for [improving reaction efficiency and selectivity].
Used in Organic Synthesis:
2,4,5-Pyrimidinetriamine, 6-(phenylmethoxy)is used as a building block for [synthesis of complex organic compounds] for [creating new molecules with potential applications].
Used in Antimicrobial Applications:
2,4,5-Pyrimidinetriamine, 6-(phenylmethoxy)is used as an antimicrobial agent for [inhibiting the growth of microorganisms] for [controlling infections and promoting health].
Used in Anticancer Applications:
2,4,5-Pyrimidinetriamine, 6-(phenylmethoxy)is used as an anticancer agent for [targeting cancer cells and inhibiting their growth] for [treating cancer and improving patient outcomes].
Used in Material Science:
2,4,5-Pyrimidinetriamine, 6-(phenylmethoxy)is used in the development of new materials for [creating innovative materials with unique properties] for [various industrial and consumer applications].
Used in Drug Discovery Research:
2,4,5-Pyrimidinetriamine, 6-(phenylmethoxy)is used as a compound in drug discovery research for [identifying potential drug candidates] for [treating various diseases and conditions].

Upstream product

• 101724-61-2 2,4-diamino-6-(benzyloxy)-5-nitrosopyrimidine 

Downstream Products

• 101092-03-9 2-amino-4-benzyloxy-6,7-dimethylpteridine 
• 124732-40-7 6-benzyloxy-2,4-diamino-5-(N'-carbomethoxythioureido)pyrimidine 
• 93251-25-3 8-carbamic acid <2-amino-6-benzyloxypurine> methyl ester 
• 195821-74-0 2-amino-4-(benzyloxy)-6-phenylpteridin-7(8H)-one 
• 737817-20-8 2-amino-O⁴-benzyl-6-hydroxymethylpteridine 
• 382607-84-3 2-(8-aza-O⁶-benzylguan-9-yl)ethyl-β-D-tetra-O-acetylglucoside 
• 6301-83-3 7-(benzyloxy)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-5-amine 
• 101720-55-2 4-benzyloxy-6-diethoxymethyl-pteridin-2-ylamine 
• 737817-22-0 2-amino-O⁴-benzyl-6-formylpteridine 

Relevant academic research and scientific papers

Triazolopyrimidines identified as reversible myeloperoxidase inhibitors

Myeloperoxidase, a mammalian peroxidase involved in the immune system as an anti-microbial first responder, can produce hypochlorous acid in response to invading pathogens. Myeloperoxidase has been implicated in several chronic pathological diseases due to the chronic production of hypochlorous acid, as well as other reactive radical species. A high throughput screen and triaging protocol was developed to identify a reversible inhibitor of myeloperoxidase toward the potential treatment of chronic diseases such as atherosclerosis. The identification and characterization of a reversible myeloperoxidase inhibitor, 7-(benzyloxy)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-5-amine is described.

Cyclin dependent kinase inhibitors

A range is disclosed of pyrimidine derivatives (I) which can act as inhibitors of cyclin dependent kinases (CDK's) and which thereby can provide useful therapeutic compounds for use in treatment of tumours or other cell proliferation disorders. The compounds of this invention bind to CDK molecules in a manner that appears to differ from that of known CDK inhibitors such as olomoucine and roscovitine. In formula (I), X is O, S or CHRxwhere Rxis H or C1-4alkyl; D is H or NZ1Z2where Z1and Z2are each independently H, C1-4alkyl, C1-4hydroxyalkyl, optionally substituted aryl or optionally substituted aralkyl; A is selected from H, C1-4alkyl, C1-4alkoxy, hydroxy, CH2(CH2)nOH (n=1-4), and NRa1Ra2where Ra1and Ra2are each independently H or C1-4alkyl; Y is or includes an optionally substituted 4- to 8-membered carbocyclic or heterocyclic ring; D′ is H or NZ3Z4where Z3and Z4are each independently H, C1-4alkyl, C1-4hydroxyalkyl, optionally substituted aryl or optionally-substituted aralkyl; E is selected from NO, NO2, N═N—Ar where Ar is an optionally substituted aryl or optionally substituted aralkyl, NRe1Re2or Nre1Nre2Re3(Re1, Re2and Re3each being independently H, C1-4alkyl, C1-4hydroxyalkyl, an optionally substituted aryl or an optionally substituted aralkyl), C(Re)═U (Rebeing hydrogen, C1-4alkyl or substituted alkyl, e.g. hydroxyalkyl, or an unsubstituted or substituted aryl or aralkyl, e.g. benzyl, and U being selected from O, Nre′, NORe′ and N—NRe′Re″ where Re′ and Re″ are each independently H, C1-4alkyl or CONH2), T, CH2T, CHT2and CT3, where T is a halide I, Br, Cl or F.

Pteridine nucleotide analogs as fluorescent DNA probes

The invention provides novel pteridine nucleotides which are highly fluorescent under physiological conditions and which may be used in the chemical synthesis of fluorescent oligonucleotidcs. The invention further provides for fluorescent oligonucleotides comprising one or more pteridine nucleotides. In addition the invention provides for pteridine nucleotide triphosphates which may be used as the constituent monomers in DNA amplification procedures.