199179-83-4Relevant academic research and scientific papers
Palladium-Catalyzed Carbonylative Synthesis of α,β-Unsaturated Amides from Styrenes and Nitroarenes
Peng, Jin-Bao,Geng, Hui-Qing,Li, Da,Qi, Xinxin,Ying, Jun,Wu, Xiao-Feng
supporting information, p. 4988 - 4993 (2018/08/24)
A procedure on palladium-catalyzed selective aminocarbonylation of styrenes with nitroarenes for the synthesis of α,β-unsaturated amides has been developed. A range of substituted α,β-unsaturated amides were synthesized in moderate to good yields. Interestingly, nitroarenes act as both a nitrogen source and oxidant, and Mo(CO)6 acts as a solid CO source and reductant in this catalytic system.
Synthesis of amides by palladium-catalyzed decarbonylative coupling of carboxylic acids with isocyanides
Huang, Lin,Guo, Haili,Pan, Lingxia,Xie, Chunsong
, p. 6027 - 6031 (2013/09/24)
Amides were synthesized from carboxylic acids and isocyanides under Pd II/AgI/base catalytic conditions. The reaction conditions were optimized, and the scope was studied. Various carboxylic acids and aryl isocyanides are compatible with this reaction, but alkyl isocyanides are not. A plausible mechanism, which features distinctive PdII-mediated decarbonylative coupling and unprecedented nucleophilic attack of carboxylates to PdII-ligated isocyanides, was proposed to account for this reaction. N-Arylamides are assembled in high yields from carboxylic acids and isocyanides under PdII/AgI/base catalytic conditions. The decarbonylative coupling features unprecedented nucleophilic attack of the carboxylate on the isocyanide, which acts as an electrophile as a result of its coordination to PdII, and this inverted reactivity is proposed to account for this transformation.
