1993-77-7

Basic information

• Product Name: 1-cyclopropyl-2,2,2-trifluoroethan-1-ol
• Synonyms: 1-cyclopropyl-2,2,2-trifluoroethan-1-ol
• CAS NO: 1993-77-7
• Molecular Formula: C₅H₇F₃O
• Molecular Weight: 140.1036896
• Mol File: 1993-77-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 75-77 °C(Press: 110 Torr)
• Appearance: /
• Density: 1.363±0.06 g/cm3(Predicted)
• PKA: 12.40±0.20(Predicted)
• CAS DataBase Reference: 1-cyclopropyl-2,2,2-trifluoroethan-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-cyclopropyl-2,2,2-trifluoroethan-1-ol(1993-77-7)
• EPA Substance Registry System: 1-cyclopropyl-2,2,2-trifluoroethan-1-ol(1993-77-7)

Safety Data

• Hazardous Substances Data: 1993-77-7(Hazardous Substances Data)

Usage

General Description

1-cyclopropyl-2,2,2-trifluoroethan-1-ol is a chemical compound with the molecular formula C5H7F3O. It is primarily used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. 1-cyclopropyl-2,2,2-trifluoroethan-1-ol is also used as a building block in the production of various organic compounds. It has a cyclopropyl group, a trifluoromethyl group, and a hydroxyl group attached to the central carbon atom, giving it unique chemical properties. The presence of the trifluoroethan-1-ol group also gives it high electronegativity and lipophilicity, which can make it useful in certain chemical reactions. Overall, 1-cyclopropyl-2,2,2-trifluoroethan-1-ol has a variety of applications in the chemical and pharmaceutical industries.

Upstream product

• 4333-56-6 cyclopropyl bromide 
• 76-05-1 trifluoroacetic acid 
• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 1489-69-6 Cyclopropanecarboxaldehyde 
• 433-27-2 ethyl trifluoroacetaldehyde hemiacetal 

Downstream Products

• 22581-19-7 cyclopropyl(trifluoromethyl)carbinyl tosylate 

Relevant articles and documents

ION CHANNEL MODULATORS

The present invention is directed to, in part, fused heteroaryl compounds and compositions useful for preventing and/or treating a disease or condition relating to aberrant function of a voltage-gated, sodium ion channel, for example, abnormal late/persistent sodium current. Methods of treating a disease or condition relating to aberrant function of a sodium ion channel including neurological disorders (e.g., Dravet syndrome, epilepsy), pain, and neuromuscular disorders are also provided herein.

Electron-Donating Ability of the Cyclopropyl Substituent in the Solvolyses of an α-CF3-Substituted Secondary-Alkyl Tosylate

The solvolysis rates of cyclopropyl(trifluoromethyl)carbinyl tosylate (1) have been determined in a series of aqueous alcohol, aqueous trifluoroethanol, and carboxylic acid solvents.Analysis of the rate data for percent internal-return isomerization and salt effects and correlation with YOTs values indicates that 1 underwent solvolysis by the kΔ pathway.Comparison of the relative ability of cyclopropyl and phenyl groups to stabilize carbocation-like transition states in solvolysis reactions of the secondary systems RCH(Y)CH3 and RCH(Y)CF3 reveals that replacement of phenyl with cyclopropyl increases the rate in both systems by a factor of 102.