19933-25-6

Usage

Uses

Used in Pharmaceutical Development:
3-(3-thienyl)-1H-pyrazole(SALTDATA: 0.7H2O) is utilized as a key intermediate in the synthesis of various pharmaceutical drugs. Its unique structure allows it to serve as a building block for the creation of novel therapeutic agents, potentially targeting a range of medical conditions.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, 3-(3-thienyl)-1H-pyrazole(SALTDATA: 0.7H2O) is employed as a research compound to explore its chemical properties and potential interactions with biological targets. This can lead to the discovery of new drug candidates and a better understanding of the compound's role in medicinal applications.
Used in Drug Design and Optimization:
3-(3-thienyl)-1H-pyrazole(SALTDATA: 0.7H2O) is used as a structural component in drug design and optimization processes. Its incorporation into drug molecules can enhance their pharmacological properties, such as potency, selectivity, and bioavailability, making it a valuable asset in the development of more effective treatments.

Upstream product

• 1468-83-3 1-(thiophen-3-yl)-ethanone 
• 79571-33-8 3-(dimethylamino)-1-(thiophen-3-yl)prop-2-en-1-one 
• 170859-75-3 3-(thiophen-3-yl)prop-2-yn-1-ol 
• 6165-69-1 Thien-3-ylboronic acid 
• 4522-35-4 3-iodo-1H-pyrazole 

Relevant academic research and scientific papers

Photoelectric properties of aromatic triangular tri-palladium complexes and their catalytic applications in the Suzuki-Miyaura coupling reaction

The photoelectric properties and catalytic activities of substituted triphenylphosphine and sulfur/selenium ligand supported aromatic triangular tri-palladium complexes1-4, abbreviated as [Pd3]+, were investigated. The cyclic voltammogram of [Pd3]+in CH3CN-nBu4NPF6showed a single quasi-reversible wave which was consistent with their robust property and provided preliminary proof for their electron transfer processes in catalysis. With excitation at 267 nm, [Pd3]+exhibited strong ratiometric fluorescence at 550 and 780 nm at a temperature gradient from 77 K to 287 K. These peculiar triangular tri-palladium complexes showed excellent catalytic activities and exclusive reactivity with aryl iodides over the other halogenated aromatics in the Suzuki-Miyaura coupling reaction. The electronic and steric hindrance effects of substituents on the aryl iodides and aryl boronic acids including heteroaromatics like pyridine, pyrazine and thiophenes were explored and most substrates achieved up to 99% of yields. (2-[1,1′-Biphenyl]-2-ylbenzothiazole) which was analogous to the selective cyclooxygenase-2 (COX-2) inhibitors was also synthesized with our tri-palladium catalyst and gave good isolated yield (94%). The study of the catalytic process revealed that the mechanism of the reaction may involve the replacement of the sulphur ligand on [Pd3]+by iodine from aryl iodides, which was beneficial for the matching of C-I bond energy.

Preparation method of pyrazole derivative (by machine translation)

The preparation method comprises the following steps: mixing an alkyne propyl alcohol derivative, a halogen source, an acid and a solvent, heating and reacting, and reacting to Meyer - Schuster generate the pyrazole derivative. Compared with the prior art, the preparation method disclosed by the invention has 91% the advantages of maximum yield, simple operation, mild conditions, high conversion rate, few byproducts and the like, and provides a brand-new synthetic method for construction of pyrazole compounds. (by machine translation)

THIENYLPYRI(MI)DINYLPYRAZOLE

Thienylpyri(mi)dinylpyrazole of the formula (I) in which R1 to R8 and X1 have the meanings given in the description, and agrochemically active salts, to their use and to methods and compositions for controlling phytopathogenic harmful fungi in and/or on plants or in and/or on seed of plants and for reducing mycotoxins in plants and parts of the plants, to processes for preparing such compounds and compositions and treated seed and also to their use for controlling phytopathogenic harmful fungi in agriculture, horticulture, forestry, in animal husbandry, in the protection of materials, in the domestic and hygiene field and for the reduction of mycotoxins in plants and parts of the plants

Studies on diazepines. VIII. Syntheses and rearrangements of 3H-1,2-pyrido- and 3H-1,2-thieno-diazepines

The previously unknown 3H-1,2-pyrido- and 3H-1,2-thieno- diazepines (3a:3H-1,2 pyrido [2,3-c] diazepine; 3b:3H-1,2 pyrido [3,2-c] diazepine; 3c:3H-1,2 thieno [2,3-c] diazepine; 3d:3H-1,2 thieno [3,2-c] diazepine) were prepared from the corresponding 1H-isomers. Treatment of 3 (the parent 3H-diazepine) with bases or acids resulted in tautomerization to give the 1H-diazepines 1 (the parent 1H-1,2 diazepine), and photolysis of 3 afforded the condensed 3-vinylpyrazoles 4 (the parent 3-vinylpyrazole). However, thermolysis of the pyridodiazepines (3a,3b) gave 4a(3-vinyl-1H-pyrido[2,3-c]pyrazole), 4b(3-vinyl-1H-pyrido[3,2-c]pyrazole), whereas the thieno-diazepines (3c,3d) gave the corresponding thienylpyrazoles (5) on irradiation via a [1,5] hydrogen shift in the diazepine ring; this mechanism was confirmed by a deuterium-labelling experiment. The 3-acetoxy-(13a) and 3-methoxy (13b) 3H-1,2-thienodiazepines were also prepared, and their photolysis afforded corresponding 3-vinylpyrazoles (14). However, thermolysis or base treatment of 13 resulted in loss of nitrogen to give the corresponding cyclopentenothiophene (15) and acetal (16).