4522-35-4

Usage

InChI:InChI=1/C3H3IN2/c4-3-1-2-5-6-3/h1-2H,(H,5,6)

Upstream product

• 141998-84-7 3-(tributylstannyl)-1H-pyrazole 
• 1820-80-0 3-aminopyrazole 
• 917899-39-9 5-iodo-pyrazole-1-sulphonic acid dimethylamide 
• 632297-52-0 2-[(5-iodopyrazol-1-yl)methoxy]ethyl trimethylsilane 

Downstream Products

• 111506-00-4 (4S,6S)-6-[2-(2,4-Dichloro-phenyl)-ethyl]-4-(3-iodo-pyrazol-1-yl)-tetrahydro-pyran-2-one 
• 92525-10-5 3-iodine-1-methyl-1H-pyrazole 
• 1621525-22-1 5-chloro-4-(3-iodo-1H-pyrazol-1-yl)-2-methoxypyridine 
• 1621525-20-9 3,5-difluoro-4-(3-iodo-1H-pyrazol-1-yl)pyridine 
• 1621525-21-0 5-fluoro-4-(3-iodo-1H-pyrazol-1-yl)-2-methoxypyridine 
• 1621525-23-2 4-(3-iodo-1H-pyrazol-1-yl)-2-methoxy-5-(trifluoromethyl)pyridine 
• 1621525-34-5 5-(3-iodo-1H-pyrazol-1-yl)-3-isopropoxypyridazine 
• 1621525-38-9 3-(tert-butoxy)-5-(3-iodo-1H-pyrazol-1-yl)pyridazine 
• 1621525-40-3 5-(3-iodo-1H-pyrazol-1-yl)-2-methylpyridazin-3(2H)-one 
• 1621525-49-2 4-(3-iodo-1H-pyrazol-1-yl)pyrimidine-2-carbonitrile 
• 1621525-47-0 5-(3-iodo-1H-pyrazol-1-yl)-2-methoxypyrimidine 
• 1621525-48-1 5-(3-iodo-1H-pyrazol-1-yl)-2-(trifluoromethyl)pyrimidine 
• 1621525-50-5 4-(3-iodo-1H-pyrazol-1-yl)-2-methylpyrimidine 
• 1621525-51-6 4-(3-iodo-1H-pyrazol-1-yl)-2-methoxypyrimidine 

Relevant academic research and scientific papers

PYRAZOLE DERIVATIVES

Provided herein are compounds of the formula I: as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment or prevention of mGluR5 mediated disorders, such as acute and/or chronic neurological disorders, cognitive disorders and memory deficits, as well as acute and chronic pain.

Sequential SNAr Reaction/Suzuki-Miyaura Coupling/C-H Direct Arylations Approach for the Rapid Synthesis of Tetraaryl-Substituted Pyrazoles

A rapid synthesis of 1,3,4,5-tetraaryl-substituted pyrazoles has been achieved through a sequence of SNAr reaction/Suzuki-Miyaura coupling/Pd-catalyzed direct arylations that used 3-iodo-1H-pyrazole as a scaffold. Pyrazoles with four different aryl groups were synthesized in a straightforward manner with no extra synthetic steps, such as protection/deprotection or the introduction of activating/directing groups, using readily available substrates and reagents. The developed synthetic approach enabled the structurally diverse synthesis of multiaryl-substituted pyrazoles without using a glovebox technique.

HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME

A hydrazide compound represented by the formula (1): has excellent pesticidal activity.

TYROSINE KINASE INHIBITORS

The present invention relates to pyridinyloxy- and pyrimidinyloxyindole derivatives, that are useful for treating cellular proliferative diseases, for treating disorders associated with MET activity, and for inhibiting the receptor tyrosine kinase MET. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.

PYRAZOLE-SUBSTITUTED AMINOHETEROARYL COMPOUNDS AS PROTEIN KINASE INHIBITORS

Compounds of formula (1) are provided, as well as methods for their synthesis and use. Preferred compounds are potent inhibitors of the c-Met protein kinase, and are useful in the treatment of abnormal cell growth disorders, such as cancers.

SYNTHESIS AND REACTION OF TRIBUTYLSTANNYLPYRAZOLES

1,3-Dipolar cycloaddition reaction of diazomethane and ethyl diazoacetate with tributylstannylacetylenes occurred regioselectively to afford the corresponding 3(5)-tributylstannylpyrazoles.The cycloaddition reaction of 3-phenylsydnone with the stannylacetylenes proceeded also regioselectively, and 3-tributylstannyl-1-phenylpyrazoles were isolated. 4-Tributylstannyl- and 5-tributylstannyl-1-phenylpyrazole were prepared by the stannylation of 4-lithio- and 5-lithio-1-phenylpyrazoles with tributylstannyl chloride.Iodination, benzoylation, and phenylation of the stannylpyrazoles were examined.