199336-05-5

Usage

Uses

Used in Pharmaceutical Industry:
TRANS (1S,2S)-1N-CBZ-CYCLOHEXANE-1,2-DIAMINE is used as a reagent for the synthesis of anti-cancer agents, specifically AA005 derivatives. It plays a crucial role in the development of novel cancer treatments by contributing to the chemical structure of these therapeutic compounds.
Additionally, it is used in the preparation of pirenzepine analogs, which are known for their antimuscarinic properties. These analogs have potential applications in the treatment of various conditions, such as gastrointestinal disorders and urinary incontinence, by blocking the action of acetylcholine on muscarinic receptors.

Upstream product

• 21436-03-3 (S,S)-1,2-diaminocyclohexane 
• 180683-64-1 tert-butyl ((1S,2S)-2-aminocyclohexyl)carbamate 
• 501-53-1 benzyl chloroformate 

Downstream Products

• 199336-06-6 {(1S,2S)-2-[(R)-2-tert-Butoxycarbonylamino-3-(4-nitro-phenyl)-propionylamino]-cyclohexyl}-carbamic acid benzyl ester 
• 1001601-36-0 C₂₈H₄₆N₂O₅ 
• 1160841-06-4 benzyl (1S,2S)-2-(trifluoromethylsulfonamido)cyclohexylcarbamate 
• 290836-18-9 (S)-2-Amino-N-((1S,2S)-2-amino-cyclohexyl)-3-(4-nitro-phenyl)-propionamide 
• 199336-07-7 {(1S,2S)-2-[(S)-2-tert-Butoxycarbonylamino-3-(4-nitro-phenyl)-propionylamino]-cyclohexyl}-carbamic acid benzyl ester 

Relevant academic research and scientific papers

Solvent-induced reversal of enantioselectivity in the synthesis of succinimides by the addition of aldehydes to maleimides catalysed by carbamate-monoprotected 1,2-diamines

A simple change in the polarity of the solvent allows both enantiomers of substituted succinimides to be obtained in the enantioselective conjugate addition reaction of aldehydes, mainly disubstituted, to maleimides catalysed by chiral carbamate-monoprote

Design, synthesis, and biological evaluation of pirenzepine analogs bearing a 1,2-cyclohexanediamine and perhydroquinoxaline units in exchange for the piperazine ring as antimuscarinics

Pirenzepine (2) is one of the most selective muscarinic M1 versus M2 receptor antagonists known. A series of 2 analogs, in which the piperazyl moiety was replaced by a cis- and trans-cyclohexane-1,2-diamine (3-6) or a trans- and cis-

A novel bifunctional sulfonamide primary amine-catalyzed enantioselective conjugate addition of ketones to nitroolefins

The enantioselective conjugate addition of a variety of ketones to nitroolefins has been developed. The process is efficiently catalyzed by a novel bifunctional sulfonamide primary amine in good yields and with good levels of enantioselectivity.

Stereochemical influence on the stability of radio-metal complexes in vivo. Synthesis and evaluation of the four stereoisomers of 2-(p- nitrobenzyl)-trans-CyDTPA

Distinct differences in in vivo stability of the two diastereomeric C- Functionalized CyDTPA chelating agents, (CHX-A DTPA and CHX-B DTPA, both racemates), as recently reported prompted further investigation as to why differences in configuration produced striking effects on the in vivo stability of their yttrium complexes. To this end, the four individual component stereoisomers of CHX-A and CHX-B were synthesized and ability to bind yttrium was investigated both in vitro and in vivo.