19934-66-8

Basic information

• Product Name: threo-(1S,2S)-2-acetamino-1-(4-nitrophenyl)-1,3-propanediol
• Synonyms: threo-(1S,2S)-2-acetamino-1-(4-nitrophenyl)-1,3-propanediol
• CAS NO: 19934-66-8
• Molecular Weight: 254.243
• Mol File: 19934-66-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: threo-(1S,2S)-2-acetamino-1-(4-nitrophenyl)-1,3-propanediol(CAS DataBase Reference)
• NIST Chemistry Reference: threo-(1S,2S)-2-acetamino-1-(4-nitrophenyl)-1,3-propanediol(19934-66-8)
• EPA Substance Registry System: threo-(1S,2S)-2-acetamino-1-(4-nitrophenyl)-1,3-propanediol(19934-66-8)

Safety Data

• Hazardous Substances Data: 19934-66-8(Hazardous Substances Data)

Upstream product

• 1846-34-0 N-(p-nitrophenacyl)acetamide 
• 108943-99-3 N-(1-acetoxy-3-oxo-3-phenylpropyl)acetamide 
• 37925-37-4 (2RS,3SR)-2-amino-3-hydroxy-3-(4-nitro-phenyl)-propionic acid ethyl ester 
• 5872-74-2 (2RS,3SR)-2-amino-3-hydroxy-3-(4-nitro-phenyl)-propionic acid 
• 74104-28-2 α-acetamido-β-hydroxypropiophenone 
• 3509-75-9 (1RS,2SR)-1,3-diacetoxy-2-acetylamino-1-phenyl-propane 
• 3313-19-7 (1RS,2SR)-2-acetylamino-1-phenyl-propane-1,3-diol 
• 3306-06-7 (1RS,2SR)-2-amino-1-phenyl-propane-1,3-diol 
• 40958-11-0 (1RS,2SR)-3-acetoxy-2-acetylamino-1-(4-nitro-phenyl)-propan-1-ol 
• 3123-13-5 N-[1-hydroxymethyl-2-(4-nitro-phenyl)-2-oxo-ethyl]-acetamide 
• 119-62-0 (1RS,2SR)-2-amino-1-(4-nitro-phenyl)-propane-1,3-diol 
• 141-78-6 ethyl acetate 
• 109162-23-4 (1RS,2SR)-1,3-diacetoxy-2-amino-1-(4-nitro-phenyl)-propane; hydrochloride 
• 18735-12-1 (+/-)-3-acetoxy-2-acetylamino-1-(4-nitro-phenyl)-propan-1-one 

Downstream Products

• 4423-58-9 N-(1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl)acetamide 
• 110461-00-2 N-[(5S)-4c-(4-nitro-phenyl)-2ξ-oxo-2λ⁴-[1,3,2]dioxathian-5r-yl]-acetamide 
• 35742-52-0 N-[(1RS,2RS)-2-(4-amino-phenyl)-2-hydroxy-1-hydroxymethyl-ethyl]-acetamide 
• 119-62-0 (+/-)-threo-1-(4-nitro-phenyl)-2-amino-1,3-propanediol 
• 50961-69-8 (1RS,2RS)-2-acetylamino-1-(4-dimethylamino-phenyl)-propane-1,3-diol 
• 110461-00-2 N-[4t-(4-nitro-phenyl)-2ξ-oxo-2λ⁴-[1,3,2]dioxathian-5r-yl]-acetamide 
• 110461-00-2 N-[4c-(4-nitro-phenyl)-2ξ-oxo-2λ⁴-[1,3,2]dioxathian-5r-yl]-acetamide 
• 88407-25-4 (2RS,3RS)-3-acetoxy-2-amino-3-(4-nitro-phenyl)-propan-1-ol; hydrochloride 
• 1885-08-1 (1RS,2RS)-2-acetylamino-1-(4-nitro-phenyl)-propane-1,3-diol 
• 52183-38-7 (+/-)-[2-methyl-5t-(4-nitro-phenyl)-4,5-dihydro-oxazol-4r-yl]-methanol 
• 15935-03-2 4-((1RS.2RS)-2-acetylamino-1,3-dihydroxy-propyl)-benzonitrile 
• 23885-61-2 4-[(1RS.2RS)-2-(2,2-dichloro-acetylamino)-1,3-dihydroxy-propyl]-benzonitrile 
• 99860-58-9 (1R,2R)-2-amino-3-dichloroacetoxy-1-(4-nitro-phenyl)-propan-1-ol 

Relevant articles and documents

Synthesis of Some Selectively N-Protected (1S,2S)-p-Nitrophenylserinol-Based Diamino-1,3-dioxanes and Tripodands

The unconventional methodology for the non-epimerizable cycloacetalization of optically active (1S,2S)-2-amino-1-(4-nitrophenyl)propane-1,3-diol (p-nitrophenylserinol) (condensed H2SO4 96% as solvent and catalyst, i.e., sulfuric transacetalization) producing (2R,4S,5S) diamino-1,3-dioxanes was enlarged by the use of N-protected forms of 2,2-dimethoxyethylamine (DMEA, aminoacetaldehyde dimethylacetal). Conversely, N-protected derivatives of p-nitrophenylserinol were successfully cyclocondensed with DMEA in the same sulfuric conditions. N-Functionalization of DMEA upon treatment with trimesic acid trichloride and cyanuric chloride yielded the corresponding triple amide and melamine, respectively. Their adapted sulfuric transacetalization in triplicate in reaction with arylserinols (aryl: phenyl, p-nitrophenyl) afforded a new series of optically active tripodands.