199388-20-0Relevant articles and documents
Enantioselective synthesis and pharmacology of 11-hydroxy-(1'S,2'R)- dimethylheptyl]-Δ8-THC
Liddle, John,Huffman, John W.,Wiley, Jenny L.,Martin, Billy R.
, p. 2223 - 2226 (1998)
An enantioselective synthesis of the (1'S,2'R)-dimethylheptyl cannabinoid side chain has been developed and employed in the synthesis of 11-hydroxy-(1'S,2'R)-dimethylheptyl-Δ8-THC (3). Pharmacology, in vivo and in vitro, indicate (3) to be one of the most potent traditional cannabinoids known.
Enantioselective synthesis of 11-hydroxy-(1′S,2′R)-dimethylheptyl-Δ8-THC, a very potent CB1 agonist
Liddle, John,Huffman, John W
, p. 7607 - 7612 (2007/10/03)
An enantioselective synthesis of the (1S,2R)-dimethylheptyl cannabinoid side chain has been developed and employed in the synthesis of 11-hydroxy-(1′S,2′R)-dimethylheptyl-Δ8-THC, one of the most potent traditional cannabinoids known. The synthesis involves a highly stereoselective addition of dimethylcopperlithium to an enoyl sultam which incorporates Opplozer's auxiliary.