199436-23-2

Upstream product

• 169478-04-0 (2R,5S,6S)-6-(N-benzyl-N-hydroxy)amino-2-phenyl-3-oxa-1-azabicyclo[3.3.0]octane-8-one 
• 134107-65-6 (3R,7aS)-3-phenyl-3,7a-dihydro-1H-pyrrolo[1,2-c]oxazol-5-one 
• 100-46-9 benzylamine 
• 622-30-0 N-benzyl hydroxylalmine 

Downstream Products

• 203982-62-1 (E)-3-[(2R,3S)-1-Acetyl-3-(acetyl-benzyl-amino)-pyrrolidin-2-yl]-acrylic acid methyl ester 
• 203982-63-2 3-[(2R,3S)-1-Acetyl-3-(acetyl-benzyl-amino)-pyrrolidin-2-yl]-propionic acid methyl ester 
• 203982-60-9 N-((2S,3S)-1-Acetyl-2-hydroxymethyl-pyrrolidin-3-yl)-N-benzyl-acetamide 
• 203982-61-0 N-((2S,3S)-1-Acetyl-2-formyl-pyrrolidin-3-yl)-N-benzyl-acetamide 
• 203982-58-5 ((2S,3S)-3-Benzylamino-pyrrolidin-2-yl)-methanol 
• 317819-18-4 [(3R,4S)-4-(Benzoyl-benzyl-amino)-1-benzyloxy-6-oxo-piperidin-3-yl]-carbamic acid tert-butyl ester 
• 317819-15-1 (2S,3S)-3-(Benzoyl-benzyl-amino)-2-(1-ethoxy-ethoxymethyl)-5-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 317819-14-0 N-benzyl-N-(5-oxo-3-phenyl-tetrahydro-pyrrolo[1,2-c]oxazol-7-yl)-benzamide 
• 216481-23-1 (2S,3S)-1-benzyl-3-(N-benzylamino)-2-hydroxymethylpyrrolidine 
• 203982-57-4 (4S,5S)-4-N-benzylamino-5-hydroxymethylpyrrolidin-2-one 

Relevant academic research and scientific papers

A short and efficient synthesis of (3S,4S)-1-benzyl-4-N-benzylamino-3- hydroxypiperidine

(3S,4S)- 1-Benzyl-4-N-benzylamino-3-hydroxypiperidine 1 was efficiently synthesized from (S)-pyroglutaminol.

Stereocontrolled synthesis of enantiopure substituted 4-aminopyrrolidin-2-ones

The highly diastereoselective conjugate addition of N-benzylhydroxylamine and benzylamine to α,β-unsaturated lactam 3 provided an efficient entry to enantiopure (4S,5S)-4-amino-5-hydroxymethylpyrrolidin-2-ones.