203982-63-2

Upstream product

• 199436-23-2 (2R,5R,6S)-6-N-benzylamino-2-phenyl-3-oxa-1-azabicyclo[3.3.0]octane-8-one 
• 203982-57-4 (4S,5S)-4-N-benzylamino-5-hydroxymethylpyrrolidin-2-one 
• 203982-60-9 N-((2S,3S)-1-Acetyl-2-hydroxymethyl-pyrrolidin-3-yl)-N-benzyl-acetamide 
• 203982-61-0 N-((2S,3S)-1-Acetyl-2-formyl-pyrrolidin-3-yl)-N-benzyl-acetamide 
• 203982-58-5 ((2S,3S)-3-Benzylamino-pyrrolidin-2-yl)-methanol 
• 203982-62-1 (E)-3-[(2R,3S)-1-Acetyl-3-(acetyl-benzyl-amino)-pyrrolidin-2-yl]-acrylic acid methyl ester 

Relevant academic research and scientific papers

Stereoselective synthesis of (2S,3S)-3-N-benzylaminoprolinol and (7S,8R)-7-N-benzylaminopyrrolizidin-3-one

The highly stereoselective synthesis of (2S,3S)-3-N-benzylaminoprolinol and derivatives involved the conjugate addition of N-benzylamine to α,β-unsaturated lactam 2. Wittig-Horner reactions with 1-acetyl-3-N-acetyl-N-benzylaminoprolinal provided a simple access to (7S,8R)-7-N-benzylaminopyrrolizidin-3-one.