944830-46-0

Upstream product

• 111-25-1 1-bromo-hexane 
• 491-67-8 5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one 
• 67047-05-6 4-oxo-2-phenyl-4H-1-benzopyran-5,6,7-triyl triacetate 
• 944830-42-6 5,6-dihydroxy-2-phenyl-7-(prop-2-en-1-yloxy)-4H-1-benzopyran-4-one 
• 944830-41-5 4-oxo-2-phenyl-7-(prop-2-en-1-yloxy)-4H-1-benzopyran-5,6-diyl diacetate 
• 944830-45-9 5,6-dibenzyloxy-7-hexyloxy-flavone 
• 199446-39-4 5,6-bis(benzyloxy)-7-hydroxy-2-phenyl-4H-1-benzopyran-4-one 
• 944830-44-8 5,6-bis(benzyloxy)-2-phenyl-7-(prop-2-en-1-yloxy)-4H-1-benzopyran-4-one 

Relevant academic research and scientific papers

Synthesis and biological evaluation of novel 7-O-lipophilic substituted baicalein derivatives as potential anticancer agents

We synthesized derivatives of baicalein, wogonin, and chrysin through alkylation at the 7-O-position of the A ring with lipophilic terphenyl or long chain n-alkyl groups, and studied the in vitro anticancer activity of the derivatives through the growth inhibition MTT assay. We discovered that baicalein and two of its derivatives were good free radical scavengers. Among the 20 synthesized derivatives, 7-O-farnesylbaicalein (5d) and 7-O-dodecylbaicalein (5i) demonstrated stronger growth inhibition against human colon cancer SW480 cells compared with baicalein, with half maximal inhibitory concentration (IC50) values of 1.15 and 1.57 μM, respectively. Furthermore, 5d and 5i dose- and time-dependently inhibited the growth of SW480 cells. Cell cycle distribution analysis showed that 5d and 5i induced SW480 cell arrest at the S phase through an apoptotic mechanism, which was associated with an increase in the generation of reactive oxygen species. In conclusion, the potent anticancer activity of the baicalein derivatives (5d and 5i) suggested that the derivatives are potential anticancer agents for human colon cancer.

Novel synthetic baicalein derivatives caused apoptosis and activated AMP-activated protein kinase in human tumor cells

Studies on the anti-proliferative activities of novel baicalein derivatives demonstrated that compounds 8 and 9 were able to activate AMPK by enhancing the levels of phosphorylated AMPKα, and showed more potent anti-proliferative effects than baicalein an