199446-76-9Relevant academic research and scientific papers
Regio- And chemoselective multiple functionalization of chloropyrazine derivatives. Application to the synthesis of coelenterazine
Mosrin, Marc,Bresser, Tomke,Knochel, Paul
, p. 3406 - 3409 (2009)
Successive regio- and chemoselective metalations of chloropyrazines using TMPMgCl-LiCl and TMPZnCIIiCI furnish, after trapping with electrophiles, highly functionalized pyrazines in high yields. Application to a synthesis of coelenterazine, a bioluminescent natural product in jellyfish Aequorea victoria, in nine steps (9% overall yield) is reported.
