199461-06-8Relevant academic research and scientific papers
A new synthesis of α-arylglycines from aryl boronic acids
Petasis, Nicos A.,Goodman, Andrew,Zavialov, Ilia A.
, p. 16463 - 16470 (1997)
Aryl and heteroaryl boronic acids react with the adducts of amines and glyoxylic acid to give the corresponding α-aryl and α-heteroaryl glycine derivatives. Several examples of this reaction with m- and p- substituted aryl boronic acids as well as 3-thienyl, 2-thienyl, 2- furyl, 2-benzo[b]furyl and 2-benzo[b]thienyl boronic acids are described.
Diastereoselective Petasis Mannich reactions accelerated by hexafluoroisopropanol: A pyrrolidine-derived arylglycine synthesis
Nanda, Kausik K.,Trotter, B. Wesley
, p. 2025 - 2028 (2007/10/03)
A diastereoselective synthesis of pyrrolidine-derived arylglycines has been developed using the Petasis boronic acid Mannich reaction. High diastereoselectivities in the reactions of chiral amines, aryl boronic acids, and glyoxylic acid monohydrate have been demonstrated for the first time. Key to the implementation of this method is the discovery that hexafluoroisopropanol accelerates the Petasis process, reducing reaction times from multiple days to less than 24 h.
Method for the synthesis of amines and amino acids with organoboron derivatives
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, (2008/06/13)
Amines and amino acids are prepared by reacting an amine, a carbonyl derivative, and an organoboron compound under mild conditions.
