A new synthesis of α-arylglycines from aryl boronic acids

Article abstract of DOI:10.1016/S0040-4020(97)01028-4

Aryl and heteroaryl boronic acids react with the adducts of amines and glyoxylic acid to give the corresponding α-aryl and α-heteroaryl glycine derivatives. Several examples of this reaction with m- and p- substituted aryl boronic acids as well as 3-thienyl, 2-thienyl, 2- furyl, 2-benzo[b]furyl and 2-benzo[b]thienyl boronic acids are described.