1995-76-2

Basic information

• Product Name: N-(2,2,2-trifluoro-1,1-diphenylethyl)acetamide
• CAS NO: 1995-76-2
• Molecular Formula: C₁₆H₁₄F₃NO
• Molecular Weight: 293.2837
• Mol File: 1995-76-2.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 406.3°C at 760 mmHg
• Flash Point: 199.5°C
• Density: 1.214g/cm³
• Vapor Pressure: 8.19E-07mmHg at 25°C
• Refractive Index: 1.517
• CAS DataBase Reference: N-(2,2,2-trifluoro-1,1-diphenylethyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2,2,2-trifluoro-1,1-diphenylethyl)acetamide(1995-76-2)
• EPA Substance Registry System: N-(2,2,2-trifluoro-1,1-diphenylethyl)acetamide(1995-76-2)

Safety Data

• Hazardous Substances Data: 1995-76-2(Hazardous Substances Data)

Upstream product

• 379-18-0 1,1-diphenyl-2,2,2-trifluoroethanol 
• 75-05-8 acetonitrile 
• 118143-24-1 2,2,2-trifluoro-1,1-diphenyl-1-(trimethylsilyloxy)ethane 
• 569-72-2 1,1-difluoro-2,2-diphenylethylene 
• 119-61-9 benzophenone 

Relevant articles and documents

Synthesis of α-CF3 and α-CF2H amines: Via the aminofluorination of fluorinated alkenes

A novel synthesis of α-CF3 and α-CF2H amines via the aminofluorination of gem-difluoroalkenes and mono-fluoroalkenes, respectively, is reported. The method employs Selectfluor as an electrophilic fluorine source and acetonitrile as a nitrogen source. Mechanistic studies revealed a single-electron oxidation/fluorine-abstraction/Ritter-type amination pathway. The protocol allowed the synthesis of a broad range of fluorinated amines including those bearing quaternary carbon centers with good efficiency and functional group tolerance.