1995-76-2Relevant academic research and scientific papers
Synthesis of α-CF3 and α-CF2H amines: Via the aminofluorination of fluorinated alkenes
Yang, Ling,Fan, Wen-Xin,Lin,Tan, Dong-Hang,Li, Qingjiang,Wang, Honggen
, p. 5907 - 5910 (2018)
A novel synthesis of α-CF3 and α-CF2H amines via the aminofluorination of gem-difluoroalkenes and mono-fluoroalkenes, respectively, is reported. The method employs Selectfluor as an electrophilic fluorine source and acetonitrile as a nitrogen source. Mechanistic studies revealed a single-electron oxidation/fluorine-abstraction/Ritter-type amination pathway. The protocol allowed the synthesis of a broad range of fluorinated amines including those bearing quaternary carbon centers with good efficiency and functional group tolerance.
One Flask Preparation of Trifluoromethylated Amides from Ketones and Trifluoromethyltrimethylsilane via Ritter Reaction with Nitriles
Tongco, Emily C.,Prakash, G.K. Surya,Olah, George A.
, p. 1193 - 1195 (2007/10/03)
Trifluoromethylated amides are prepared in a simple one-flask reaction via the Ritter reaction of the corresponding trifluoromethylated silyl ethers, which themselves are readily obtained from the starting ketones and trifluoromethyltrimethylsilane. The y
