199522-62-8Relevant academic research and scientific papers
Discovery of a novel non-peptide somatostatin agonist with SST4 selectivity
Ankersen, Michael,Crider, Michael,Liu, Shengquan,Ho, Bin,Andersen, Henrik S.,Stidsen, Carsten
, p. 1368 - 1373 (2007/10/03)
The discovery of novel non-peptide compounds with a high affinity for the peptide hormone somatostatin (SST) receptor is described. The compounds were tested for affinity at five human SST receptor subtypes individually expressed in mammalian cells. The c
Nonpeptide somatostatin agonists with sst4 selectivity: Synthesis and structure-activity relationships of thioureas
Liu, Shenquan,Tang, Cheng,Ho, Bin,Ankersen, Michael,Stidsen, Carsten E.,Crider, A. Michael
, p. 4693 - 4705 (2007/10/03)
Utilizing NNC 26-9100 (11) as a structural lead, a variety of nonpeptide derivatives of somatostatin were synthesized and evaluated for sst2 and sst4 receptor binding affinity. A novel thiourea scaffold was utilized to attach (1) a h
