199587-26-3Relevant academic research and scientific papers
Reactivity of p-Phenyl Substituted β-Enamino Compounds using K-10/ultrasound. I. Synthesis of Pyrazoles and Pyrazolinones
Valduga, Claudete J.,Braibante, Hugo S.,Braibante, Mara E.F.
, p. 189 - 192 (2007/10/03)
The reactivity of the β-enamino ketones, 3-amino-l-(p-phenyl-substituted)-2-buten-l-ones la-d and β-enamino esters. Ethyl-3-amino-3-(p-phenyl-substituted)-2-propenoates 5a-d were evaluated by systematic studies of the reactions with hydrazine and methylhydrazine by reactions with solid support K-10/ultrasound and homogeneous media (reflux in ethanol or dichloromethane) yielding pyrazole rings 2a-d, Af-methylpyrazoles 3a-d, 4a-d and N-methylpyrazolinones 6a-c and 7a-c. The regiochemistry of the cyclization showed dependence of the reaction conditions employed as well as the substituent in the aromatic ring.
Reactivity of p-phenyl substituted β-enamino compounds using K- 10/ultrasound. I. Synthesis of pyrazoles and pyrazolinones
Valduga,Braibante,Braibante
, p. 1453 - 1457 (2007/10/03)
The reactivity of the β-enamino ketones, 3-amino-1-(p-phenyl- substituted)-2-buten-1-ones 1a-d and β-enamino esters, ethyl 3-amino-3-(p- phenyl-substituted)-2-propenoates 5a-d was systematically studied when allowed to react with hydrazine and methylhydrazine under solid support K- 10/ultrasound conditions and in homogeneous media (reflux in ethanol or dichloromethane). The products were pyrazoles 2a-d, N-methylpyrazoles 3a-d, 4a-d and N-methylpyrazolinones 6a-c and 7a-c. The regiochemistry of the cyclization reactions showed dependence upon the reaction conditions employed as well as upon the substituent in the aromatic ring.
