199589-61-2Relevant articles and documents
NOVEL PYRIMIDO[4,5-d]PYRIMIDIN-2-ONE DERIVATIVES AS PROTEIN KINASE INHIBITORS
-
Paragraph 0362-0382, (2021/03/30)
The present invention is a pyrimido [4, 5-d] pyrimid -2 -one derivative compound showing an excellent anti-proliferative effect on cancer cells. The present invention relates to a pharmaceutically acceptable salt, a hydrate thereof, a stereoisomer thereof, a pharmaceutical composition for preventing, alleviating or treating cancer metastasis and proliferative diseases containing the same as an active ingredient, and an anticancer composition comprising the same as an active ingredient.
Introducing efficient palladium catalyzed cross coupling reaction of tertiary alcohols and aroyl chlorides for the synthesis of highly substituted esters
Al-Masum, Mohammad,Hira, Arpona,Chrisman, Sara,Nguyen, Ngan T.
, (2019/07/22)
Esters are chemical compounds with many practical uses. The common type of esterification is called the Fischer esterification. Another one is by the action of acid chlorides on alcohols but not with tertiary alcohols. The stable carbenium ions formed fro
COMPOUNDS WITH ANTI-TUMORAL ACTIVITY
-
Page/Page column 73, (2016/09/22)
The present invention relates to compounds of general formula (I), wherein A represents an optionally substituted heterocycle group, B represents an aryl or heteroaryl group and wherein X, R1, R2, R3, R4 and R5 are as defined in the description. Compounds of formula (I) are useful to destroy, inhibit, or prevent the growth or spread of cells, especially malignant cells, into surrounding tissues implicated in a variety of human and animal diseases.