199589-61-2

Upstream product

• 96-98-0 4-methyl-3-nitrobenzoic acid 
• 75-65-0 tert-butyl alcohol 
• 10397-30-5 4-methyl-3-nitrobenzoyl chloride 
• 111773-25-2 tert-butyl 3-amino-4-methylbenzoate 

Downstream Products

• 1230717-88-0 C₁₅H₂₀N₂O₄ 
• 111773-25-2 tert-butyl 3-amino-4-methylbenzoate 
• 1352298-28-2 C₃₀H₃₅ClN₄O₄S 
• 1352298-27-1 C₂₀H₂₁ClN₂O₃ 
• 1352298-26-0 C₂₀H₁₉ClN₂O₅ 
• 1352298-25-9 C₁₄H₁₅NO₆ 
• 1352298-24-8 C₁₆H₁₉NO₆ 
• 1070885-15-2 C₂₆H₂₇ClN₄O₄S 
• 321886-31-1 tert-butyl 4-formyl-3-nitrobenzoate 

Relevant academic research and scientific papers

NOVEL PYRIMIDO[4,5-d]PYRIMIDIN-2-ONE DERIVATIVES AS PROTEIN KINASE INHIBITORS

The present invention is a pyrimido [4, 5-d] pyrimid -2 -one derivative compound showing an excellent anti-proliferative effect on cancer cells. The present invention relates to a pharmaceutically acceptable salt, a hydrate thereof, a stereoisomer thereof, a pharmaceutical composition for preventing, alleviating or treating cancer metastasis and proliferative diseases containing the same as an active ingredient, and an anticancer composition comprising the same as an active ingredient.

PYRIMIDO[4,5-D]PYRIMIDIN-2-ONE DERIVATIVES AS PROTEIN KINASE INHIBITORS

Disclosed are a compound selected from novel pyrimido[4,5-d]pyrimidin-2-one derivative compounds having excellent anti-proliferative activity against cancer cells, pharmaceutically acceptable salts thereof, hydrates thereof and stereoisomers thereof, a method for preparing the compound, a pharmaceutical composition for preventing, alleviating or treating cancer metastasis and proliferative diseases containing the compound as an active ingredient, and an anticancer composition against cancer cells, containing the compound as an active ingredient. The compounds of this invention exhibit most excellent selective inhibitory activity agaist LCK and anti-proliferative activity against cancer cells, thus being useful for inhibiting cancer cells, and for preventing or treating cancer metastasis and proliferative diseases.

Introducing efficient palladium catalyzed cross coupling reaction of tertiary alcohols and aroyl chlorides for the synthesis of highly substituted esters

Esters are chemical compounds with many practical uses. The common type of esterification is called the Fischer esterification. Another one is by the action of acid chlorides on alcohols but not with tertiary alcohols. The stable carbenium ions formed fro

PISTON FOR AN INTERNAL COMBUSTION ENGINE AND METHOD FOR PRODUCING THE PISTON FOR AN INTERNAL COMBUSTION ENGINE

The present invention relates to compounds of general formula (I), wherein A represents an optionally substituted heterocycle group, B represents an aryl or heteroaryl group and wherein X, R1, R2, R3, R4 and R5 are as defined in the description. Compounds of formula (I) are useful to destroy, inhibit, or prevent the growth or spread of cells, especially malignant cells, into surrounding tissues implicated in a variety of human and animal diseases.

COMPOUNDS WITH ANTI-TUMORAL ACTIVITY

The present invention relates to compounds of general formula (I), wherein A represents an optionally substituted heterocycle group, B represents an aryl or heteroaryl group and wherein X, R1, R2, R3, R4 and R5 are as defined in the description. Compounds of formula (I) are useful to destroy, inhibit, or prevent the growth or spread of cells, especially malignant cells, into surrounding tissues implicated in a variety of human and animal diseases.

Synthetic, structural mimetics of the β-hairpin flap of HIV-1 protease inhibit enzyme function

Small-molecule mimetics of the β-hairpin flap of HIV-1 protease (HIV-1 PR) were designed based on a 1,4-benzodiazepine scaffold as a strategy to interfere with the flap-flap protein-protein interaction, which functions as a gated mechanism to control acce

THERAPEUTIC AGENT FOR CEREBRAL INFARCTION

The invention provides a therapeutic drug for ischemic stroke. The therapeutic drug has the formula (I) wherein each symbol is as defined herein, or a pharmacologically acceptable salt thereof, or a solvate thereof, as an active ingredient.

Orally active zwitterionic factor Xa inhibitors with long duration of action

We have optimized 2-aminomethylphenylamine derivative as a factor Xa inhibitor. Several polar functional groups were introduced in the central phenyl ring, and we focused on zwitter ionic compound showing continuous inhibitory activity in oral administrat

Selective colorimetric sensing of anions in aqueous media through reversible covalent bonding

(Chemical Equation Presented) Selective colorimetric sensing of anions in aqueous media has been studied, which involves reversible covalent bonding as key binding interactions. By introducing a simple nitro chromophore into an o-(carboxamido)trifluoroace