199601-80-4

Basic information

• Product Name: 5-(3-NITROPHENYL)-3-ISOXAZOLECARBOXYLIC ACID
• Synonyms: 5-(3-NITROPHENYL)-3-ISOXAZOLECARBOXYLIC ACID;5-(3-Nitrophenyl)isoxazole-3-carboxylic Acid
• CAS NO: 199601-80-4
• Molecular Formula: C10H6N2O5
• Molecular Weight: 234.16
• Mol File: 199601-80-4.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 5-(3-NITROPHENYL)-3-ISOXAZOLECARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(3-NITROPHENYL)-3-ISOXAZOLECARBOXYLIC ACID(199601-80-4)
• EPA Substance Registry System: 5-(3-NITROPHENYL)-3-ISOXAZOLECARBOXYLIC ACID(199601-80-4)

Safety Data

• Hazardous Substances Data: 199601-80-4(Hazardous Substances Data)

Usage

General Description

5-(3-Nitrophenyl)-3-isoxazolecarboxylic acid is a chemical compound with the molecular formula C10H6N2O5. It is an isoxazole derivative containing a carboxylic acid functional group and a nitrophenyl group. 5-(3-NITROPHENYL)-3-ISOXAZOLECARBOXYLIC ACID is commonly used as a synthetic intermediate in organic chemistry and pharmaceutical research. It is also known for its potential biological activity and has been studied for its potential role in medicinal chemistry. The presence of the nitro group in the molecule makes it a useful building block for the synthesis of various bioactive compounds.

Upstream product

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Relevant articles and documents

Design and synthesis of novel 5-arylisoxazole-1,3,4-thiadiazole hybrids as α-glucosidase inhibitors

Background: α-Glucosidase inhibitors have occupied a significant position in the treatment of type 2 diabetes. In this respect, the development of novel and efficient non-sugar-based inhibitors is in high demand. Objective: Design and synthesis of new 5-arylisoxazole-1,3,4-thiadiazole hybrids possessing α-glucosidase inhibitory activity were developed. Methods: Different derivatives were synthesized by the reaction of various 5-arylisoxazole-3-carboxylic acids and ethyl 2-((5-amino-1,3,4-thiadiazol-2-yl)thio)acetate. Finally, they were evalu-ated for their α-glucosidase inhibitory activity. Results: It was found that ethyl 2-((5-(5-(2-chlorophenyl)isoxazole-3-carboxamido)-1,3,4-thiadiazol-2-yl)thio)acetate (5j) was the most potent compound (IC50 = 180.1 μM) compared with acarbose as the reference drug (IC50 = 750.0 μM). Also, the kinetic study of 5j revealed a competitive inhibition and docking study results indicated desired interactions of that compound with amino acid residues located close to the active site of α-glucosidase. Conclusion: Good α-glucosidase inhibitory activity obtained by the title compounds introduced them as an efficient scaffold, which merits to be considered in anti-diabetic drug discovery developments.

Design and Synthesis of Selective Acetylcholinesterase Inhibitors: Arylisoxazole-Phenylpiperazine Derivatives

In this work, a novel series of arylisoxazole-phenylpiperazines were designed, synthesized, and evaluated toward acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Our results revealed that [5-(2-chlorophenyl)-1,2-oxazol-3-yl](4-phenylpiperazin

Synthesis and biochemical evaluation of N-(4-phenylthiazol-2- yl)benzenesulfonamides as high-affinity inhibitors of kynurenine 3- hydroxylase

In this paper we describe the synthesis, structure-activity relationship (SAR), and biochemical characterization of N-(4-phenylthiazol-2- yl)benzenesulfonamides as inhibitors of kynurenine 3-hydroxylase. The compounds 3,4-dimethoxy-N-[4-(3-nitrophenyl)thi