199601-80-4

Usage

Uses

Used in Organic Chemistry:
5-(3-Nitrophenyl)-3-isoxazolecarboxylic acid is used as a synthetic intermediate for the development of various organic compounds. Its unique structure and functional groups facilitate its use in the synthesis of complex organic molecules.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 5-(3-Nitrophenyl)-3-isoxazolecarboxylic acid is employed as a key intermediate in the synthesis of potential drug candidates. Its presence in the molecular structure can contribute to the biological activity of the resulting compounds, making it a valuable component in medicinal chemistry.
Used in Medicinal Chemistry:
5-(3-Nitrophenyl)-3-isoxazolecarboxylic acid is used as a building block for the synthesis of bioactive compounds in medicinal chemistry. The nitro group in its structure can be further modified or reduced to form amines, which can enhance the biological activity of the synthesized compounds.
Used in the Synthesis of Bioactive Compounds:
5-(3-Nitrophenyl)-3-isoxazolecarboxylic acid is utilized in the synthesis of bioactive compounds due to its potential biological activity. The presence of the nitro group allows for further chemical modifications, leading to the development of compounds with therapeutic potential.

Upstream product

• 586-39-0 1-nitro-3-vinyl-benzene 
• 199601-82-6 5-(3-nitrophenyl)-4,5-dihydroisoxazole-3-carbonitrile 
• 121-89-1 3-Nitroacetophenone 
• 57961-49-6 ethyl 4-(3-nitrophenyl)-2,4-dioxobutanoate 
• 866040-66-6 ethyl 5-(3-nitrophenyl)isoxazole-3-carboxylate 
• 199602-07-8 5-(3-nitrophenyl)-isoxazole-3-carbonitrile 

Relevant academic research and scientific papers

Design and synthesis of novel 5-arylisoxazole-1,3,4-thiadiazole hybrids as α-glucosidase inhibitors

Background: α-Glucosidase inhibitors have occupied a significant position in the treatment of type 2 diabetes. In this respect, the development of novel and efficient non-sugar-based inhibitors is in high demand. Objective: Design and synthesis of new 5-arylisoxazole-1,3,4-thiadiazole hybrids possessing α-glucosidase inhibitory activity were developed. Methods: Different derivatives were synthesized by the reaction of various 5-arylisoxazole-3-carboxylic acids and ethyl 2-((5-amino-1,3,4-thiadiazol-2-yl)thio)acetate. Finally, they were evalu-ated for their α-glucosidase inhibitory activity. Results: It was found that ethyl 2-((5-(5-(2-chlorophenyl)isoxazole-3-carboxamido)-1,3,4-thiadiazol-2-yl)thio)acetate (5j) was the most potent compound (IC50 = 180.1 μM) compared with acarbose as the reference drug (IC50 = 750.0 μM). Also, the kinetic study of 5j revealed a competitive inhibition and docking study results indicated desired interactions of that compound with amino acid residues located close to the active site of α-glucosidase. Conclusion: Good α-glucosidase inhibitory activity obtained by the title compounds introduced them as an efficient scaffold, which merits to be considered in anti-diabetic drug discovery developments.

Design and Synthesis of Novel Arylisoxazole-Chromenone Carboxamides: Investigation of Biological Activities Associated with Alzheimer's Disease

A novel series of hybrid arylisoxazole-chromenone carboxamides were designed, synthesized, and evaluated for their cholinesterase (ChE) inhibitory activity based on the modified Ellman's method. Among synthesized compounds, 5-(3-nitrophenyl)-N-{4-[(2-oxo-

Design and Synthesis of Selective Acetylcholinesterase Inhibitors: Arylisoxazole-Phenylpiperazine Derivatives

In this work, a novel series of arylisoxazole-phenylpiperazines were designed, synthesized, and evaluated toward acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Our results revealed that [5-(2-chlorophenyl)-1,2-oxazol-3-yl](4-phenylpiperazin

Novel indole-isoxazole hybrids: Synthesis and in vitro anti-cholinesterase activity

Background: This work reports synthesis and in vitro cholinesterase inhibitory activity of novel indole-isoxazole hybrids. Method: The synthetic procedure was started from different ethyl 5-Arylisoxazole-3-carboxylate derivatives. Hydrolysis and reaction

Synthesis and biochemical evaluation of N-(4-phenylthiazol-2- yl)benzenesulfonamides as high-affinity inhibitors of kynurenine 3- hydroxylase

In this paper we describe the synthesis, structure-activity relationship (SAR), and biochemical characterization of N-(4-phenylthiazol-2- yl)benzenesulfonamides as inhibitors of kynurenine 3-hydroxylase. The compounds 3,4-dimethoxy-N-[4-(3-nitrophenyl)thi