19968-55-9

Basic information

• Product Name: 2,4-dimethyl-5-phenylthiazole
• Synonyms: 2,4-dimethyl-5-phenylthiazole
• CAS NO: 19968-55-9
• Molecular Weight: 189.281
• Mol File: 19968-55-9.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 2,4-dimethyl-5-phenylthiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-dimethyl-5-phenylthiazole(19968-55-9)
• EPA Substance Registry System: 2,4-dimethyl-5-phenylthiazole(19968-55-9)

Safety Data

• Hazardous Substances Data: 19968-55-9(Hazardous Substances Data)

Upstream product

• 23022-83-5 1-bromo-1-phenyl-2-propanone 
• 62-55-5 thioacetamide 
• 16735-28-7 N-(1-methyl-2-oxo-2-phenylethyl)acetamide 
• 541-58-2 2,4-dimethylthiazole 
• 108-86-1 bromobenzene 
• 53137-27-2 2,4-dimethyl-thiazole-5-carboxylic acid 
• 591-50-4 iodobenzene 
• 101743-36-6 2,5-dimethyl-3,6-diphenyl-[1,4]dithiane-2,5-diol 
• 60-35-5 acetamide 
• 103858-99-7 2,4-dimethyl-5-phenyl-2,5-dihydro-thiazole 
• 412312-66-4 2-benzyl-2,4-dimethyl-5-phenyl-2,5-dihydro-thiazole 

Downstream Products

• 25020-70-6 1-(3-bromo-4-ethoxy-phenyl)-3-[4-(2,4-dimethyl-thiazol-5-yl)-phenyl]-thiourea 
• 25179-39-9 1-(4-butoxy-phenyl)-3-[4-(2,4-dimethyl-thiazol-5-yl)-phenyl]-thiourea 
• 25179-40-2 1-(3-bromo-4-methoxy-phenyl)-3-[4-(2,4-dimethyl-thiazol-5-yl)-phenyl]-thiourea 
• 25020-66-0 1-[4-(2,4-dimethyl-thiazol-5-yl)-phenyl]-3-(4-propoxy-phenyl)-thiourea 
• 25179-38-8 1-[4-(2,4-dimethyl-thiazol-5-yl)-phenyl]-3-(4-isopropoxy-phenyl)-thiourea 
• 25179-41-3 1-(3,4-dichloro-phenyl)-3-[4-(2,4-dimethyl-thiazol-5-yl)-phenyl]-thiourea 
• 25179-37-7 1-[4-(2,4-dimethyl-thiazol-5-yl)-phenyl]-3-(4-ethoxy-phenyl)-thiourea 
• 25020-65-9 1-[4-(2,4-dimethyl-thiazol-5-yl)-phenyl]-3-(4-methoxy-phenyl)-thiourea 
• 25021-64-1 4-(2,4-dimethylthiazol-5-yl)aniline 

Relevant articles and documents

Direct (Hetero)arylation of Heteroarenes Catalyzed by Unsymmetrical Pd-PEPPSI-NHC Complexes under Mild Conditions

With the aim of developing a facile and efficient method to access structurally intriguing and valuable functionalized (hetero)aryls, two unsymmetrical Pd-PEPPSI-type NHC complexes (PEPPSI, pyridine-enhanced precatalyst preparation, stabilization, and initiation; NHC, N-heterocyclic carbene) were designed and synthesized to catalyze the direct arylation of heteroarenes with (hetero)aryl bromides. The results demonstrated that the utilization of this "unsymmetrical"strategy led to much higher efficiency in comparison to the commonly used C2-symmetric Pd-PEPPSI-type NHC complexes. Furthermore, a broad range of heteroaromatics and (hetero)aryl bromide partners with a wide variety of functional groups were all amenable to the developed protocol even at as low as 0.05 mol % catalyst loading and under aerobic conditions. More importantly, along with our study, we also found that the present protocol could provide expedient access to the gram-scale synthesis of the muscle relaxant drug dantrolene and conjugated mesopolymers.

Camphyl-based α-diimine palladium complexes: Highly efficient precatalysts for direct arylation of thiazoles in open-air

Based on the strategy of the development of phosphine-free palladium-catalyzed direct C-H arylation, a series of camphyl-based α-diimine palladium complexes bearing sterically bulky substituents were synthesized and characterized. The palladium complexes

Decarboxylative cross-coupling of azoyl carboxylic acids with aryl halides

Decarboxylative cross-coupling of thiazole and oxazole-5-carboxylic acids with aryl halides is reported. Under a bimetallic system of catalytic palladium and a stoichiometric silver carbonate, a variety of (hetero)arylated azoles can be prepared in excell