19970-13-9

Upstream product

• 7677-24-9 trimethylsilyl cyanide 
• 108-94-1 cyclohexanone 
• 106-47-8 4-chloro-aniline 
• 151-50-8 potassium cyanide 
• 64269-06-3 1-(phenylamino)cyclohexanecarbonitrile 

Downstream Products

• 19970-01-5 1--cyclohexancarbonsaeure-(1)-nitril 
• 19969-97-2 1-<2.4-Dichlor-anilino>-cyclohexancarbonsaeure-(1)-nitril 
• 19970-00-4 1--cyclohexancarbonsaeure-(1)-nitril 

Relevant academic research and scientific papers

Gallic acid-functionalized magnetic nanoparticles: a convenient and green approach for synthesis of α-aminonitriles under solvent-free conditions

Abstract: Gallic acid-coated magnetic nanoparticles were efficiently prepared, characterized by Fourier transform infrared spectroscopy, X-ray diffraction, vibrating sample magnetometry, scanning electron microscopy, and transmission electron microscopy, and employed as an environmentally friendly and recyclable catalyst for one-pot synthesis of three-component reaction via Strecker reaction, incorporating aldehydes/ketones, amines, and trimethylsilyl cyanides under solvent-free conditions. Operational simplicity, product purity, natural resources and reusability of the catalyst are considered as evident features of this protocol which will hopefully develop into an inexpensive, efficient, and clean strategy for the synthesis of α-aminonitriles. Graphical abstract: [Figure not available: see fulltext.].

Fe3O4/MIL-101(Fe) nanocomposite as an efficient and recyclable catalyst for Strecker reaction

A highly porous metal-organic framework, MIL-101(Fe), was prepared by a solvothermal method in the presence of amino-modified Fe3O4@SiO2 nanoparticles, in order to achieve Fe3O4/MIL-101(Fe) nanocomposite, which was characterized by XRD, FT-IR, SEM, TEM, BET, and VSM. This hybrid magnetic nanocomposite was employed as heterogeneous catalyst for α-amino nitriles synthesis through three-component condensation reaction of aldehydes (ketones), amines, and trimethylsilyl cyanide in EtOH, at room temperature. The recoverability and reusability was admitted for the heterogeneous magnetic catalyst; no significant reduction of catalytic activity was observed even after five consecutive reaction cycles.

Nanostructured oxytyramine catalyst for the facile one-pot synthesis of cyclohexanecarbonitrile derivatives

The magnetic, recyclable heterogeneous organocatalyst OT@Si@SPIONs has been developed in this report, with the aim of synthesizing cyclohexanecarbonitriles. The prepared nanocatalyst was fully characterized by various techniques and its catalytic activity

Synthesis of α-aminonitriles under mild catalytic, metal-free conditions

α-Aminonitriles have been synthesized by a Strecker synthesis from aldehydes and ketones under mild catalytic, metal-free conditions. Aromatic aldehydes (1 equiv) were reacted with aromatic and 1 or 2 aliphatic amines (1 equiv) in EtOH containing 3 mol %

Sulfamic acid-functionalized magnetic Fe3O4 nanoparticles as an efficient and reusable catalyst for one-pot synthesis of α-amino nitriles in water

Grafting of chlorosulfuric acid on the amino-functionalized Fe 3O4 nanoparticles afforded sulfamic acid-functionalized magnetic Fe3O4 nanoparticles (SA-MNPs) as a novel organic-inorganic hybrid heterogeneous catalyst, which was characterized by XRD, FT-IR, TGA, TEM, and elemental analysis. The catalytic activity of SA-MNPs was probed through one-pot synthesis of α-amino nitriles via three-component couplings of aldehydes (or ketones), amines and trimethylsilyl cyanide in water, at room temperature. The heterogeneous catalyst could be recovered easily and reused many times without significant loss of its catalytic activity.

Synthesis of new imidazolidinones, spiro-imidazolidinones and spiro-hydantoins

α-Alkyl/aryl-α-arylaminopropionitriles (1) and 1-arylamino-1-cyano-cyclohexanes/cyclopentanes (5) react with alkyl/arylisocyanates to afford new imidazolidinones (2, 3) and spiro-imidazolidinones (6, 7) respectively. Compounds 2 and 6 on hydrolysis give hydantoins (4) and spiro-hydantoins (8), respectively.