199730-17-1Relevant articles and documents
Chlorocatechelins A and B from streptomyces sp.: New siderophores containing chlorinated catecholate groups and an acylguanidine structure
Kishimoto, Shinji,Nishimura, Shinichi,Hattori, Akira,Tsujimoto, Masafumi,Hatano, Masaki,Igarashi, Masayuki,Kakeya, Hideaki
, p. 6108 - 6111 (2014)
Two novel siderophores, chlorocatechelins A and B, were isolated from a culture broth of Streptomyces sp. Their structures were determined by spectroscopic analysis and degradation study. They contain chloro-substituted catecholate that has not been reported in natural products, whereas this group was conjugated to guanidine to form acylguanidine in chlorocatechelin A. This acylguanidine decomposed in weakly acidic solutions to furnish a less potent siderophore chlorocatechelin B. Chemical and biological insights into acylguanidine are also discussed.
New cytotoxic callipeltins from the Solomon Island marine sponge Asteropus sp.
Stierhof, Marc,Hansen, Kine ?stnes,Sharma, Mukesh,Feussner, Klaus,Subko, Karolina,Díaz-Rullo, Fernando Fernández,Isaksson, Johan,Pérez-Victoria, Ignacio,Clarke, David,Hansen, Espen,Jaspars, Marcel,Tabudravu, Jioji N.
, p. 6929 - 6934 (2016/10/14)
Four new callipeltin A derivatives (N–Q) have been isolated from the Solomon Island marine sponge Asteropus sp. Their structures were established by spectroscopic techniques followed by acid hydrolysis and derivatisation of the free amino acids, and subsequent LCMS analysis of the derivatives. The compounds were evaluated for their activity against cancer cell lines A2058 (melanoma), HT-29 (colorectal adenocarcinoma) and MCF-7 (breast adenocarcinoma) and non-malignant MRC-5 fibroblast cells. While the acyclic callipeltins P and Q were inactive the cyclic callipeltins N and O showed significant cytotoxicity against all exposed cell lines with IC50values as low as 0.16?μM confirming the role of cyclic configuration in biological activity.
Stictamides A-C, MMP12 inhibitors containing 4-amino-3-hydroxy-5- phenylpentanoic acid subunits
Liang, Zhibin,Sorribas, Analia,Sulzmaier, Florian J.,Jimenez, Jorge I.,Wang, Xin,Sauvage, Thomas,Yoshida, Wesley Y.,Wang, Guangyi,Ramos, Joe W.,Williams, Philip G.
experimental part, p. 3635 - 3643 (2011/06/24)
An extensive study of the secondary metabolites produced by a new Sticta sp. of lichen has led to the isolation of three new compounds containing the 4-amino-3-hydroxy-5-phenylpentanoic acid residue (Ahppa). The structures of stictamides A-C (1-3) were as
