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157-06-2

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157-06-2 Usage

Description

D-arginine is the D-form of arginine, which is a kind of amino acids. It can be reacted with hydrogen peroxide for non-enzymatic synthesis of nitric oxide. It has certain pharmacological activities. For example, its derivative, 1-deamino-8-D-arginine vasopressin is useful for the management of haemophilia and von Willebrand’s disease. It also has the potential to inhibit the proliferation of certain cancer cells. In biological research, D-arginine is frequently used in the studies of L-arginine/nitric oxide pathway as an inactive form of L-arginine.

Chemical Properties

white to light yellow crystal powde

Uses

Different sources of media describe the Uses of 157-06-2 differently. You can refer to the following data:
1. Arginine is an essential amino acid found in food and plant sources, and many biological systems. D-Arginine is extensively used in studies on L-arginine/nitric oxide pathway as an inactive form of L-arginine, even in man. D-Arginine is slightly soluble (in water) and a moderately acidic compound (based on its pKa). D-Arginine can be found in human epidermis and platelet tissues. Within the cell, D-arginine is primarily located in the peroxisome. D-Arginine specifically can inhibit arginine decarboxylase enzymes and also functions as a metabolite.
2. 1-Deamino-8-D-arginine vasopressin makes a new pharmacological approach to the management of haemophilia and von Willebrand's disease. A novel nonenzymatic pathway for the generation of nitric oxide is by the reaction of hydrogen peroxide and d- or l-arginine.

Definition

ChEBI: A D-alpha-amino acid that is the D-isomer of arginine.

References

https://www.alfa.com/zh-cn/catalog/A16137/ Iannucci, N. B., et al. "Antiproliferative effect of 1-deamino-8-D-arginine vasopressin analogs on human breast cancer cells." Future Medicinal Chemistry 3.16(2011):1987-1993. Ripoll, Giselle, et al. "Angiostatic activity of 1-Deamino-8-D-Arginine vasopressin and novel peptide analogues in breast cancer cells." Cancer Research 68(2008). Navarro, Eduardo, et al. "Toxicological and Pharmacological Effects of D-Arginine." Basic & Clinical Pharmacology & Toxicology97.3(2005):149-154.

Check Digit Verification of cas no

The CAS Registry Mumber 157-06-2 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,5 and 7 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 157-06:
(5*1)+(4*5)+(3*7)+(2*0)+(1*6)=52
52 % 10 = 2
So 157-06-2 is a valid CAS Registry Number.
InChI:InChI=1/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/t4-/m1/s1

157-06-2 Well-known Company Product Price

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  • TCI America

  • (A1029)  D-(-)-Arginine  >98.0%(T)

  • 157-06-2

  • 1g

  • 280.00CNY

  • Detail
  • TCI America

  • (A1029)  D-(-)-Arginine  >98.0%(T)

  • 157-06-2

  • 5g

  • 890.00CNY

  • Detail
  • Alfa Aesar

  • (A16137)  D-Arginine, 98%   

  • 157-06-2

  • 1g

  • 320.0CNY

  • Detail
  • Alfa Aesar

  • (A16137)  D-Arginine, 98%   

  • 157-06-2

  • 5g

  • 1372.0CNY

  • Detail
  • Sigma

  • (A2646)  D-Arginine  ≥98% (TLC)

  • 157-06-2

  • A2646-250MG

  • 327.60CNY

  • Detail
  • Sigma

  • (A2646)  D-Arginine  ≥98% (TLC)

  • 157-06-2

  • A2646-1G

  • 871.65CNY

  • Detail
  • Sigma

  • (A2646)  D-Arginine  ≥98% (TLC)

  • 157-06-2

  • A2646-5G

  • 3,001.05CNY

  • Detail

157-06-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name D-arginine

1.2 Other means of identification

Product number -
Other names D-ARG

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:157-06-2 SDS

157-06-2Synthetic route

(2R)-2-acetamido-5-guanidino-pentanoate
2389-86-8

(2R)-2-acetamido-5-guanidino-pentanoate

D-arginine
157-06-2

D-arginine

Conditions
ConditionsYield
With hydrogenchloride

A

D-arginine
157-06-2

D-arginine

B

L-arginine
74-79-3

L-arginine

(R)-5-Guanidino-2-[(1H-indole-3-carbonyl)-amino]-pentanoic acid

(R)-5-Guanidino-2-[(1H-indole-3-carbonyl)-amino]-pentanoic acid

A

1H-indole-3-carboxylic acid
771-50-6

1H-indole-3-carboxylic acid

B

D-arginine
157-06-2

D-arginine

Conditions
ConditionsYield
With hydrogenchloride at 120℃; for 12h; Product distribution;
DL-arginine

DL-arginine

D-arginine
157-06-2

D-arginine

Conditions
ConditionsYield
With arginase
copper (II)-compound of D-ornithine

copper (II)-compound of D-ornithine

O-methyl-isothiourea

O-methyl-isothiourea

D-arginine
157-06-2

D-arginine

Conditions
ConditionsYield
With sodium hydroxide anschliessend mit H2S;
carbonate dl-arginine

carbonate dl-arginine

A

D-arginine
157-06-2

D-arginine

B

d-ornithine , urea

d-ornithine , urea

Conditions
ConditionsYield
With water at 37℃; bei der Einwirkung von Leberpresssaft (Arginase) bleibt das l-Arginin bestehen, waehrend das d-Arginin gespalten wird;
neamphamide A

neamphamide A

D-arginine
157-06-2

D-arginine

Conditions
ConditionsYield
With hydrogenchloride In water at 107℃; for 18.5h;
(-)-leptoclinidamine B trifluoroacetic acid salt

(-)-leptoclinidamine B trifluoroacetic acid salt

D-arginine
157-06-2

D-arginine

Conditions
ConditionsYield
With hydrogenchloride In water at 100℃; for 8h;
neamphamide B

neamphamide B

A

D-allo-threonine
24830-94-2

D-allo-threonine

B

L-leucine
61-90-5

L-leucine

C

L-asparagine
70-47-3

L-asparagine

D

D-arginine
157-06-2

D-arginine

E

gamma-Glutamylmethylamide

gamma-Glutamylmethylamide

F

pipecolinic acid
3105-95-1

pipecolinic acid

Conditions
ConditionsYield
With hydrogenchloride In water at 120℃; for 16h;
neamphamide C

neamphamide C

A

D-allo-threonine
24830-94-2

D-allo-threonine

B

L-leucine
61-90-5

L-leucine

C

L-asparagine
70-47-3

L-asparagine

D

D-arginine
157-06-2

D-arginine

E

N-methyl-L-glutamic acid
6753-62-4

N-methyl-L-glutamic acid

F

pipecolinic acid
3105-95-1

pipecolinic acid

Conditions
ConditionsYield
With hydrogenchloride In water at 120℃; for 16h;
neamphamide D

neamphamide D

A

D-allo-threonine
24830-94-2

D-allo-threonine

B

L-leucine
61-90-5

L-leucine

C

L-asparagine
70-47-3

L-asparagine

D

D-arginine
157-06-2

D-arginine

E

gamma-Glutamylmethylamide

gamma-Glutamylmethylamide

F

pipecolinic acid
3105-95-1

pipecolinic acid

Conditions
ConditionsYield
With hydrogenchloride In water at 120℃; for 16h;
callipeltin N

callipeltin N

A

D-Alanine
338-69-2

D-Alanine

B

D-Threonine
632-20-2

D-Threonine

C

L-leucine
61-90-5

L-leucine

D

D-arginine
157-06-2

D-arginine

E

pipecolinic acid
3105-95-1

pipecolinic acid

Conditions
ConditionsYield
With hydrogenchloride In water at 110℃; for 24h;
callipeltin O

callipeltin O

A

D-Alanine
338-69-2

D-Alanine

B

D-Threonine
632-20-2

D-Threonine

C

L-leucine
61-90-5

L-leucine

D

D-arginine
157-06-2

D-arginine

E

pipecolinic acid
3105-95-1

pipecolinic acid

Conditions
ConditionsYield
With hydrogenchloride In water at 110℃; for 24h;
callipeltin P

callipeltin P

A

D-Alanine
338-69-2

D-Alanine

B

D-Threonine
632-20-2

D-Threonine

C

L-leucine
61-90-5

L-leucine

D

D-arginine
157-06-2

D-arginine

E

pipecolinic acid
3105-95-1

pipecolinic acid

Conditions
ConditionsYield
With hydrogenchloride In water at 110℃; for 24h;
callipeltin Q

callipeltin Q

A

D-Alanine
338-69-2

D-Alanine

B

D-Threonine
632-20-2

D-Threonine

C

L-leucine
61-90-5

L-leucine

D

D-arginine
157-06-2

D-arginine

E

pipecolinic acid
3105-95-1

pipecolinic acid

Conditions
ConditionsYield
With hydrogenchloride In water at 110℃; for 24h;
D-3-bromocamphor-10-sulfonic acid ammonium salt
56144-54-8

D-3-bromocamphor-10-sulfonic acid ammonium salt

A

D-arginine
157-06-2

D-arginine

B

L-arginine D-3-bromocamphor-10-sulfonic acid salt

L-arginine D-3-bromocamphor-10-sulfonic acid salt

Conditions
ConditionsYield
In methanol at 20 - 60℃; for 2h;
(1S,3S,4S)-3-bromocamphor-10-sulfonic acid
67999-30-8

(1S,3S,4S)-3-bromocamphor-10-sulfonic acid

A

D-arginine
157-06-2

D-arginine

B

L-arginine D-3-bromocamphor-10-sulfonic acid salt

L-arginine D-3-bromocamphor-10-sulfonic acid salt

Conditions
ConditionsYield
In methanol at 20 - 60℃; for 2h;
methanol
67-56-1

methanol

D-arginine
157-06-2

D-arginine

methyl (2R)-2-amino-5-carbamimidamidopentanoate dihydrochloride
22888-59-1, 26340-89-6, 78851-84-0, 111237-99-1, 18598-71-5

methyl (2R)-2-amino-5-carbamimidamidopentanoate dihydrochloride

Conditions
ConditionsYield
With thionyl chloride95%
With thionyl chloride Ambient temperature;
D-arginine
157-06-2

D-arginine

N-t-butoxycarbonyl-L-phenylalanine 4-nitrophenyl ester
7535-56-0

N-t-butoxycarbonyl-L-phenylalanine 4-nitrophenyl ester

(tert-butoxycarbonyl)-L-phenylalanyl-D-arginine

(tert-butoxycarbonyl)-L-phenylalanyl-D-arginine

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 20℃; for 24h; Condensation;90%
D-arginine
157-06-2

D-arginine

S-(-)-9-fluoro-6,7-dihydro-8-(4-hydroxypiperidin-1-yl)-5-methyl-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylic acid
154357-42-3

S-(-)-9-fluoro-6,7-dihydro-8-(4-hydroxypiperidin-1-yl)-5-methyl-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylic acid

S-(-)-9-fluoro-6,7-dihydro-8-(4-hydroxypiperidin-1-yl)-5-methyl-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylic acid D-arginine salt
627891-14-9

S-(-)-9-fluoro-6,7-dihydro-8-(4-hydroxypiperidin-1-yl)-5-methyl-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylic acid D-arginine salt

Conditions
ConditionsYield
In methanol; water at 60 - 65℃; for 0.25h;88%
In methanol; water at 60 - 65℃; for 0.25h;88%
ferrocenecarboxaldehyde
12093-10-6

ferrocenecarboxaldehyde

D-arginine
157-06-2

D-arginine

C10H9FeCHNCH(COOH)(CH2)3NHC(NH2)NH

C10H9FeCHNCH(COOH)(CH2)3NHC(NH2)NH

Conditions
ConditionsYield
With sodium carbonate In ethanol boiling;87%
With Na2CO3 In ethanol boiling;87%
D-arginine
157-06-2

D-arginine

tert-butylisonitrile
119072-55-8, 7188-38-7

tert-butylisonitrile

(2S,4S,5R,6S)-6-isobutyl-2-((2R,3S)-3-isobutylaziridin-2-yl)-3-oxa-1-aza-bicyclo[3.1.0]hexan-4-ol
1215325-21-5

(2S,4S,5R,6S)-6-isobutyl-2-((2R,3S)-3-isobutylaziridin-2-yl)-3-oxa-1-aza-bicyclo[3.1.0]hexan-4-ol

(3R,5S,6S,7S)-N-tert-butyl-3-(3-guanidinopropyl)-7-isobutyl-2-oxo-1,4-diazabicyclo[4.1.0]heptane-5-carboxamide
1215324-80-3

(3R,5S,6S,7S)-N-tert-butyl-3-(3-guanidinopropyl)-7-isobutyl-2-oxo-1,4-diazabicyclo[4.1.0]heptane-5-carboxamide

Conditions
ConditionsYield
In 1,1,1,3',3',3'-hexafluoro-propanol at 20℃; for 1h; optical yield given as %de;83%
D-arginine
157-06-2

D-arginine

benzyl chloroformate
501-53-1

benzyl chloroformate

Nα-Z-D-Arg
6382-93-0

Nα-Z-D-Arg

Conditions
ConditionsYield
With sodium hydroxide; sodium hydrogencarbonate82%
5-carboxymethyl-6-azauracil N-succinimidyl ester

5-carboxymethyl-6-azauracil N-succinimidyl ester

D-arginine
157-06-2

D-arginine

N1-[(6-azauracil-5-yl)methylcarbonyl]-D-arginine

N1-[(6-azauracil-5-yl)methylcarbonyl]-D-arginine

Conditions
ConditionsYield
In 1,4-dioxane; water at 20℃;80%
N-(benzyloxycarbonyl)-D-alanine N-hydroxysuccinimide ester
27167-53-9

N-(benzyloxycarbonyl)-D-alanine N-hydroxysuccinimide ester

D-arginine
157-06-2

D-arginine

Z-D-Ala-D-Arg-OH hydrochloride

Z-D-Ala-D-Arg-OH hydrochloride

Conditions
ConditionsYield
Stage #1: N-(benzyloxycarbonyl)-D-alanine N-hydroxysuccinimide ester; D-arginine In water; acetonitrile at 20℃;
Stage #2: With hydrogenchloride In water; acetonitrile pH=2.5;
73%
D-arginine
157-06-2

D-arginine

9H-fluorene-2-carbaldehyde
30084-90-3

9H-fluorene-2-carbaldehyde

C20H24N4O2

C20H24N4O2

Conditions
ConditionsYield
Stage #1: D-arginine; 9H-fluorene-2-carbaldehyde In methanol for 6h; Reflux;
Stage #2: With sodium tetrahydroborate In methanol at 20℃; for 1h;
68%
D-arginine
157-06-2

D-arginine

Z(OMe)-Tyr-N3
66854-58-8

Z(OMe)-Tyr-N3

Z(OMe)-Tyr-D-Arg-OH HCl
74863-19-7

Z(OMe)-Tyr-D-Arg-OH HCl

Conditions
ConditionsYield
With triethylamine In water; N,N-dimethyl-formamide at 4℃; for 48h;62%
D-arginine
157-06-2

D-arginine

N-(fluoren-9-ylmethoxycarbonyl)glycine
29022-11-5

N-(fluoren-9-ylmethoxycarbonyl)glycine

meta-aminobenzoic acid
99-05-8

meta-aminobenzoic acid

trifluoroacetic acid
76-05-1

trifluoroacetic acid

6-((S)-1-{[(E)-Allyloxycarbonylimino]-amino-methyl}-3-tert-butoxycarbonylamino-piperidin-2-yloxy)-hexanoic acid
241146-47-4

6-((S)-1-{[(E)-Allyloxycarbonylimino]-amino-methyl}-3-tert-butoxycarbonylamino-piperidin-2-yloxy)-hexanoic acid

3-((R)-2-Amino-5-guanidino-pentanoylamino)-N-[((S)-1-carbamimidoyl-2-hydroxy-piperidin-3-ylcarbamoyl)-methyl]-benzamide; compound with trifluoro-acetic acid

3-((R)-2-Amino-5-guanidino-pentanoylamino)-N-[((S)-1-carbamimidoyl-2-hydroxy-piperidin-3-ylcarbamoyl)-methyl]-benzamide; compound with trifluoro-acetic acid

Conditions
ConditionsYield
With aminomethylated polystyrene resin Solid phase reaction;48%
toluenic phosgene

toluenic phosgene

6-chloropurinyl pentanol

6-chloropurinyl pentanol

D-arginine
157-06-2

D-arginine

N,N-dimethylaminopurinyl pentoxycarbonyl D-arginine

N,N-dimethylaminopurinyl pentoxycarbonyl D-arginine

Conditions
ConditionsYield
With sodium hydrogencarbonate; dimethyl amine In tetrahydrofuran; methanol; water; acetone43%
With sodium hydrogencarbonate; dimethyl amine In tetrahydrofuran; methanol; water; acetone43%
D-arginine
157-06-2

D-arginine

2,4,6-trifluoropyrimidine
696-82-2

2,4,6-trifluoropyrimidine

A

N-(4,6-Difluoro-2-pyrimidyl)-D-arginine

N-(4,6-Difluoro-2-pyrimidyl)-D-arginine

B

N-(2,6-Difluoro-4-pyrimidyl)-D-arginine

N-(2,6-Difluoro-4-pyrimidyl)-D-arginine

Conditions
ConditionsYield
With sodium carbonate In water at 50℃; for 2h; Yields of byproduct given;A 40%
B n/a
With sodium carbonate In water at 50℃; for 2h; Yield given; Title compound not separated from byproducts;A 40%
B n/a
copper(II) choride dihydrate

copper(II) choride dihydrate

D-arginine
157-06-2

D-arginine

pyridine-3,5-dicarboxylate

pyridine-3,5-dicarboxylate

Cu(2+)*2NH2C(NH)NHCH2CH2CH2CH(NH2)COOH*C5H3N(COO)2(2-)*5H2O=[Cu(C6H14N4O2)2](C5H3N(COO)2)*5H2O

Cu(2+)*2NH2C(NH)NHCH2CH2CH2CH(NH2)COOH*C5H3N(COO)2(2-)*5H2O=[Cu(C6H14N4O2)2](C5H3N(COO)2)*5H2O

Conditions
ConditionsYield
With NaOH In water stoichiometric ratio Cu:L; diffusion of EtOH;30%
D-arginine
157-06-2

D-arginine

benzyl chloroformate
501-53-1

benzyl chloroformate

tri-carbobenzoxy arginine sodium salt

tri-carbobenzoxy arginine sodium salt

Conditions
ConditionsYield
With sodium hydroxide In water at 0℃; for 0.5h;15%
ethanol
64-17-5

ethanol

D-arginine
157-06-2

D-arginine

N,N'-diacetylglycylglycine ethyl ester
151079-65-1

N,N'-diacetylglycylglycine ethyl ester

Ac-Gly-Gly-OEt
3757-98-0

Ac-Gly-Gly-OEt

D-arginine
157-06-2

D-arginine

2-Bromopropionic acid
598-72-1

2-Bromopropionic acid

A

Nα-((R)-1-carboxy-ethyl)-D-arginine
63358-48-5

Nα-((R)-1-carboxy-ethyl)-D-arginine

B

Nα-((S)-1-carboxy-ethyl)-D-arginine
63358-46-3

Nα-((S)-1-carboxy-ethyl)-D-arginine

Conditions
ConditionsYield
With water
D-arginine
157-06-2

D-arginine

N,N'-diacetylglycylglycine ethyl ester
151079-65-1

N,N'-diacetylglycylglycine ethyl ester

Ac-Gly-Gly-OEt
3757-98-0

Ac-Gly-Gly-OEt

Conditions
ConditionsYield
With sodium hydroxide
With ethanol
D-arginine
157-06-2

D-arginine

2,5-diaminopentanoic acid
70-26-8, 348-66-3, 616-07-9, 7006-33-9

2,5-diaminopentanoic acid

Conditions
ConditionsYield
bei der Faeulnis;
D-arginine
157-06-2

D-arginine

N-nitro-L-arginine
2149-70-4

N-nitro-L-arginine

Conditions
ConditionsYield
With sulfuric acid; nitric acid nitro-d-arginine;
D-arginine
157-06-2

D-arginine

A

L-ornithine
70-26-8

L-ornithine

B

urea
57-13-6

urea

Conditions
ConditionsYield
bei der Einw. von Leberpresssaft;
With barium dihydroxide
With arginase
D-arginine
157-06-2

D-arginine

5-aminopentanoic acid
660-88-8

5-aminopentanoic acid

Conditions
ConditionsYield
bei der Faeulnis;
ethanol
64-17-5

ethanol

D-arginine
157-06-2

D-arginine

N,N'-diacetylpiperazin-2,5-dione
3027-05-2

N,N'-diacetylpiperazin-2,5-dione

N,N'-diacetylglycylglycine ethyl ester
151079-65-1

N,N'-diacetylglycylglycine ethyl ester

Conditions
ConditionsYield
at 20℃;
N-(benzyloxycarbonyl)-phenylalanine-N-hydroxysuccinimide ester
3397-32-8

N-(benzyloxycarbonyl)-phenylalanine-N-hydroxysuccinimide ester

D-arginine
157-06-2

D-arginine

(R)-2-((S)-2-Benzyloxycarbonylamino-3-phenyl-propionylamino)-5-guanidino-pentanoic acid
88263-48-3

(R)-2-((S)-2-Benzyloxycarbonylamino-3-phenyl-propionylamino)-5-guanidino-pentanoic acid

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 20℃; for 12h;
D-arginine
157-06-2

D-arginine

C11H13ClN4O3
114153-81-0

C11H13ClN4O3

Nα-{[5-(6-hydroxypurin-9-yl)pentoxy]carbonyl}-D-arginine

Nα-{[5-(6-hydroxypurin-9-yl)pentoxy]carbonyl}-D-arginine

Conditions
ConditionsYield
With sodium hydrogencarbonate In tetrahydrofuran Yield given;
D-arginine
157-06-2

D-arginine

C11H13ClN4O2

C11H13ClN4O2

Nα-{[5-(purin-9-yl)pentoxy]carbonyl}-D-arginine

Nα-{[5-(purin-9-yl)pentoxy]carbonyl}-D-arginine

Conditions
ConditionsYield
With sodium hydrogencarbonate In tetrahydrofuran Yield given;

157-06-2Relevant articles and documents

Two new tryptamine derivatives, leptoclinidamide and (-)-leptoclinidamine B, from an Indonesian ascidian Leptoclinides dubius

Yamazaki, Hiroyuki,Wewengkang, Defny S.,Nishikawa, Teruaki,Rotinsulu, Henki,Mangindaan, Remy E. P.,Namikoshi, Michio

, p. 349 - 357 (2012)

Two new tryptamine-derived alkaloids, named as leptoclinidamide (1) and (-)-leptoclinidamine B (2), were isolated from an Indonesian ascidian Leptoclinides dubius together with C2-α-D-mannosylpyranosyl-L- tryptophan (3). The structure of 1 was assigned on the basis of spectroscopic data for 1 and its N-acetyl derivative (4). Compound 1 was an amide of tryptamine with two β-alanine units. Although the planar structure of 2 is identical to that of the known compound (+)-leptoclinidamine B (5), compound 2 was determined to be the enantiomer of 5 based on amino acid analysis using HPLC methods. Compounds 1 to 4 were evaluated for cytotoxicity against two human cancer cell lines, HCT-15 (colon) and Jurkat (T-cell lymphoma) cells, but none of the compounds showed activity.

Preparation and characterization of a new open-tubular capillary column for enantioseparation by capillary electrochromatography

Li, Yingjie,Tang, Yimin,Qin, Shili,Li, Xue,Dai, Qiang,Gao, Lidi

, p. 283 - 292 (2019/02/05)

In order to use the enantioseparation capability of cationic cyclodextrin and to combine the advantages of capillary electrochromatography (CEC) with open-tubular (OT) column, in this study, a new OT-CEC, coated with cationic cyclodextrin (1-allylimidazolium-β-cyclodextrin [AI-β-CD]) as chiral stationary phase (CSP), was prepared and applied for enantioseparation. Synthesized AI-β-CD was characterized by infrared (IR) spectrometry and mass spectrometry (MS). The preparation conditions for the AI-β-CD-coated column were optimized with the orthogonal experiment design L9(34). The column prepared was characterized by scanning electron microscopy (SEM) and elemental analysis (EA). The results showed that the thickness of stationary phase in the inner surface of the AI-β-CD-coated columns was about 0.2 to 0.5?μm. The AI-β-CD content in stationary phase based on the EA was approximately 2.77?mmol·m?2. The AI-β-CD-coated columns could separate all 14 chiral compounds (histidine, lysine, arginine, glutamate, aspartic acid, cysteine, serine, valine, isoleucine, phenylalanine, salbutamol, atenolol, ibuprofen, and napropamide) successfully in the study and exhibit excellent reproducibility and stability. We propose that the column, coated with AI-β-CD, has a great potential for enantioseparation in OT-CEC.

METHOD FOR PREPARING D-ARGININE

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Paragraph 0026-0035, (2017/09/02)

Disclosed is a method of preparing D-arginine, wherein D-arginine is obtained by the optical resolution of DL-arginine using D-3-bromocamphor-10-sulfonic acid as an optical resolving agent.

SEPARATING AGENT AND MANUFACTURING METHOD THEREOF

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Paragraph 0067; 0068; 0069; 0070; 0071; 0072;, (2015/01/07)

An embodiment of the present invention is a separating agent wherein a group represented by a chemical formula of: or a group represented by a chemical formula of: is introduced on a surface thereof.

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