1997387-43-5 Usage
Uses
PZM21 is a potent Gi activator with exceptional selectivity for μOR and minimal β-arrestin-2 recruitment. PZM21 is an experimental opioid analgesic drug that is being researched for the treatment of pain. It is a functionally selective μ-opioid receptor agonist which produces μ-opioid receptor mediated G protein signaling, with potency and efficacy similar to morphine, but with less β-arrestin 2 recruitment. In tests on mice, PZM21 was slightly less potent than morphine or TRV130 as an analgesic, but also had significantly reduced adverse effects, with less constipation than morphine, and very little respiratory depression, even at high doses.
Check Digit Verification of cas no
The CAS Registry Mumber 1997387-43-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,9,9,7,3,8 and 7 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1997387-43:
(9*1)+(8*9)+(7*9)+(6*7)+(5*3)+(4*8)+(3*7)+(2*4)+(1*3)=265
265 % 10 = 5
So 1997387-43-5 is a valid CAS Registry Number.
1997387-43-5Relevant articles and documents
MU OPIOID RECEPTOR MODULATORS
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Paragraph 0416; 0472-0477, (2018/07/31)
Described herein, inter alia, are compositions and methods for modulating mu opioid receptor activity.
MU OPIOID RECEPTOR MODULATORS
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Paragraph 0424-0429, (2017/01/26)
Described herein, inter alia, are compositions and methods for modulating mu opioid receptor activity.
