199797-87-0

Upstream product

• 154003-21-1 ((2S,4S)-2-((1H-1,2,4-triazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl)methyl 4-methyl-benzenesulfonate 
• 74853-07-9 2,4-dihydro-4-[4-[4-(4-methoxyphenyl)-1-piperazinyl ]-phenyl]-3H-1,2,4-triazol-3-one 

Downstream Products

• 148626-66-8 2S,4R,2'S,3'S hydroxy itraconazole 

Relevant academic research and scientific papers

Application of 3'-hydroxyitraconazole

The invention discloses an application of 3'-hydroxyitraconazole, and in particular discloses an application of the 3'-hydroxyitraconazole in preparation of a medicine for reducing mTOR signal transduction activity. The 3'-hydroxyitraconazole can reduce the mTOR signal transduction activity, and can be used for treating or preventing cell proliferation diseases, treating and preventing cancers, preventing or regulating cancer cells and cancer metastasis, and treating or preventing rheumatoid arthritis, retinopathy, maculopathy, skin diseases and lupus erythematosus.

Efficient stereoselective synthesis of cis, syn-hydroxyitraconazole isomers

The first stereoselective synthesis of cis, syn-hydroxyitraconazole isomers via a tricomponent coupling strategy is described. The isomers are prepared from two chiral subunits and connected via an achiral linker. A highly stereoselective route to the cis,syn-isomers is presented.