19986-15-3Relevant academic research and scientific papers
Enantioselective synthesis of allenecarboxylates from phenyl acetates through C-C bond forming reactions
Yamazaki, Jiro,Watanabe, Toshiyuki,Tanaka, Kiyoshi
, p. 669 - 675 (2007/10/03)
A variety of optically active 4,4-disubstituted allenecarboxylic acid methyl esters were prepared from simple α,α-disubstituted phenyl acetate through base treatment of the esters to generate ketenes, followed by successive Horner-Wadsworth-Emmons reaction. The transformation was further developed as a one-pot procedure with satisfactory yields and high enantioselectivity.
