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199863-76-8

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199863-76-8 Usage

Chemical Structure

It is a pyrimidine derivative.

Functional Groups

Amino group at the 2-position
Hydroxyl group at the 4-position

Pharmaceutical Applications

Studied for anti-inflammatory and anti-arthritic properties
Potential treatment for conditions like rheumatoid arthritis and autoimmune diseases

Research Focus

Investigating its role in modulating the immune response
Potential inhibition of inflammatory cytokines production

Promising Therapeutic Agent

Shows promise for treating a range of inflammatory and autoimmune conditions

Ongoing Research

Continual investigation into its therapeutic potential and mechanisms of action.

Check Digit Verification of cas no

The CAS Registry Mumber 199863-76-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,9,8,6 and 3 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 199863-76:
(8*1)+(7*9)+(6*9)+(5*8)+(4*6)+(3*3)+(2*7)+(1*6)=218
218 % 10 = 8
So 199863-76-8 is a valid CAS Registry Number.

199863-76-8Relevant articles and documents

Discovery and SAR of 6-alkyl-2,4-diaminopyrimidines as histamine H 4 receptor antagonists

Savall, Brad M.,Chavez, Frank,Tays, Kevin,Dunford, Paul J.,Cowden, Jeffery M.,Hack, Michael D.,Wolin, Ronald L.,Thurmond, Robin L.,Edwards, James P.

, p. 2429 - 2439 (2014/04/17)

This report discloses the discovery and SAR of a series of 6-alkyl-2-aminopyrimidine derived histamine H4 antagonists that led to the development of JNJ 39758979, which has been studied in phase II clinical trials in asthma and atopic dermatitis. Building on our SAR studies of saturated derivatives from the indole carboxamide series, typified by JNJ 7777120, and incorporating knowledge from the tricyclic pyrimidines led us to the 6-alkyl-2,4-diaminopyrimidine series. A focused medicinal chemistry effort delivered several 6-alkyl-2,4-diaminopyrimidines that behaved as antagonists at both the human and rodent H4 receptor. Further optimization led to a panel of antagonists that were profiled in animal models of inflammatory disease. On the basis of the preclinical profile and efficacy in several animal models, JNJ 39758979 was selected as a clinical candidate; however, further development was halted during phase II because of the observation of drug-induced agranulocytosis (DIAG) in two subjects.

2-Aminopyrimidine modulators of the histamine H4 receptor

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Page/Page column 11, (2008/12/07)

2-Aminopyrimidine compounds are described, which are useful as H4 receptor modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by H4 /su

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