199926-80-2

Upstream product

• 145822-68-0 (E)-[2-ethoxy-3-(ethoxycarbonyl)-2-propenylidene]triphenylphosphorane 
• 72155-45-4 Boc-L-phenylalaninal 

Downstream Products

• 199927-20-3 (4S,5S)-(-)-5-(3-ethoxycarbonyl-2-oxo)propyl-3-(N-methyl)-4-benzyl-2-oxazolidinone 
• 272772-50-6 (4S,5S)-(-)-4-benzyl-5-(2,4-dihydroxybutyl)-3-(N-4-methoxybenzyl)-2-oxazolidinone 
• 272772-52-8 (4S,5S)-(-)-4-benzyl-5-(2,2-dimethyl-1,3-dioxan-4-ylmethyl)-3-N-(4-methoxybenzyl)-2-oxazolidinone 
• 272772-40-4 (4S,5S)-(-)-4-benzyl-5-(3-ethoxycarbonyl-2-oxo)propyl-3-N-(4-methoxybenzyl)-2-oxazolidinone 
• 272772-49-3 (4S,5S)-(-)-4-benzyl-5-(3-ethoxycarbonyl-2-hydroxopropyl)-3-N-(4-methoxybenzyl)-2-oxazolidinone 
• 199926-94-8 ethyl (S)-(-)-6-(N-tert-butoxycarbonyl-N-methyl)amino-3-ethoxy-7-phenylhepta-2,4-dienoate 
• 271585-88-7 ethyl 1-(N-tert-butoxycarbonyl)-5-benzyl-2-pyrrolylacetate 
• 272772-39-1 ethyl (S)-(-)-6-(N-tert-butoxycarbonyl-N-4-methoxybenzyl)amino-3-ethoxy-7-phenylhepta-2,4-dienoate 

Relevant academic research and scientific papers

Synthesis and reaction of chiral 4,5-disubstituted 2-oxazolidinones from 3-ethoxy-6-(N-alkyl-N-tert-butoxy- carbonyl)aminohexa-2,4-dienoates in the presence of concentrated sulfuric acid supported on silica gel

Reaction of chiral 3-ethoxy-6-(N-alkyl-N-tert-butoxycarbonyl)amino-hexa- 2,4-dienoates (3) and related compounds with 97% concentrated sulfuric acid supported on silica gel proceeded stereo- and regio-selectively to yield chiral 4,5-disubstituted N-alkyl-2-oxazolidinones (7). Under the limited conditions, 7 were converted into N-alkyl-2-pyrrolylacetates (8) and 2- oxazolidinone derivatives (12) which may serve as a chiral auxiliary.

A facile synthesis of 5-substituted 2-furyl-, 2-thienyl- and 2- pyrrolylacetates by cyclodehydration of γ-functionalized α,β-unsaturated ketones

Synthesis of 5-substituted 2-furyl-, 2-thienyl- and 2-pyrrolylacetates is achieved by acid-catalyzed cyclodehydration of γ-hydroxy (γ-acetylthio and γ-amino)-α,β-unsaturated ketones generated from ethyl 6-substituted 3- ethoxy-6-hydroxy-(6-acetylthio and 6-amino)hexa-2,4-dienoates which are easily accessible from α-functionalized carbonyl compounds and Wittig reagents.