199928-07-9Relevant academic research and scientific papers
Synthesis of a pyrido[2,3-d]pyrimidine analogue of the multitargeted antifolate LY231514
Taylor, Edward C.,Lee, Koo
, p. 2229 - 2237 (2007/10/03)
Syntheses of pyrido[2,3-d]pyrimidines (9) and (21), ring-expanded analogues of the antitumor agent LY231514 (7), and its 4-amino analog, respectively, are described. Preliminary in vitro cell culture evaluation has shown that expansion of the pyrrole ring of the latter two pyrrolo[2,3-d]pyrimidines through introduction of a carbonyl group between positions 6 and 7 results in complete loss of cell growth inhibitory activity.
