151937-09-6

Basic information

• Product Name: 3-[4-(Methoxycarbonyl)phenyl]propanoic acid
• Synonyms: 3-[4-(Methoxycarbonyl)phenyl]propanoic acid;4-(2-Carboxyethyl)benzoic Acid Methyl Ester;Benzenepropanoic acid, 4-(methoxycarbonyl)-
• CAS NO: 151937-09-6
• Molecular Formula: C₁₁H₁₂O₄
• Molecular Weight: 208.21058
• Product Categories: Aromatics, Intermediates
• Mol File: 151937-09-6.mol

Chemical Properties

• Boiling Point: 360.5±25.0 °C(Predicted)
• Appearance: /
• Density: 1 +-.0.06 g/cm3(Predicted)
• Solubility: Methanol
• PKA: 4.55±0.10(Predicted)
• CAS DataBase Reference: 3-[4-(Methoxycarbonyl)phenyl]propanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-[4-(Methoxycarbonyl)phenyl]propanoic acid(151937-09-6)
• EPA Substance Registry System: 3-[4-(Methoxycarbonyl)phenyl]propanoic acid(151937-09-6)

Safety Data

• Hazardous Substances Data: 151937-09-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3-[4-(Methoxycarbonyl)phenyl]propanoic acid is used as an intermediate in the preparation of a potential inhibitor of GAR Tfase, an enzyme involved in the metabolism of amino acids. This application is significant for the development of new therapeutic strategies targeting metabolic disorders and diseases.
Used in Chemical Synthesis:
As a phenylpropanoic acid derivative, 3-[4-(Methoxycarbonyl)phenyl]propanoic acid is used as a building block in the synthesis of various organic compounds, including pharmaceuticals, agrochemicals, and other specialty chemicals. Its versatile structure allows for further functionalization and modification to create a wide range of products with different applications.
Used in Research and Development:
3-[4-(Methoxycarbonyl)phenyl]propanoic acid is also utilized in research and development settings to study its chemical properties, reactivity, and potential applications in various fields. This includes exploring its use in the development of new materials, catalysts, and other advanced technologies.

Upstream product

• 117390-07-5 (E)-4-(methoxycarbonyl)cinnamic acid 
• 40912-11-6 3-(4-(methoxycarbonyl)phenyl)propanoic acid methyl ester 
• 1571-08-0 methyl 4-formylbenzoate 
• 19473-96-2 4-(2-carboxyvinyl)benzoic acid methyl ester 

Downstream Products

• 74733-36-1 methyl 4-(2-cyanoethyl)benzoate 
• 852812-64-7 1,1,1-trifluoro-4-(4-(methoxycarbonyl)phenyl)butan-2-one 
• 852812-69-2 4-[5-(2,4-Diamino-6-oxo-1,6-dihydro-pyrimidin-5-yl)-2-(2,2,2-trifluoro-acetyl)-pentyl]-benzoic acid 
• 914262-53-6 di-tert-butyl N-{4-[5-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-2-(2,2,2-trifluoroacetyl)pentyl]benzoyl}-L-glutamate 
• 199928-07-9 4-(4-Ethoxycarbonyl-3-oxo-butyl)-benzoic acid 
• 199928-04-6 4-(4-Ethoxycarbonyl-3-oxo-butyl)-benzoic acid methyl ester 
• 149010-52-6 1-chloro-4-(4-carbomethoxyphenyl)-2-butanone 
• 151937-10-9 N-4-<2-(2-amino-4(3H)-oxo-7H-pyrrolo<2,3-d>pyrimidin-6-yl)ethyl>benzoic acid 
• 136784-88-8 methyl N-4-<2-(2-amino-4(3H)-oxo-7H-pyrrolo<2,3-d>pyrimidin-6-yl)ethyl> benzoate 
• 151937-11-0 dimethyl N-<4-<2-(2-amino-4(3H)-oxo-7H-pyrrolo<2,3-d>pyrimidin-6-yl)ethyl>benzoyl>-L-glutamate 
• 177736-04-8 methyl 4-[2-(tert-butoxycarbonylamino)ethyl]benzoate 

Relevant articles and documents

Preparation method of pemetrexed acid

Belonging to the technical field of organic compound synthesis, the invention in particular relates to a preparation method of pemetrexed acid. The method is characterized by utilizing methyl p-formylbenzoate and malonic acid as the starting materials to synthesize the target product. Compared with the methods for synthesis of the compound reported in previous literatures, the method provided by the invention has the advantages of easily available raw materials, low price and no pollution, greatly reduces the production cost, and is suitable for large-scale industrial production. The method isa brand new synthetic route for the compound.

A biocompatible alkene hydrogenation merges organic synthesis with microbial metabolism

Organic chemists and metabolic engineers use orthogonal technologies to construct essential small molecules such as pharmaceuticals and commodity chemicals. While chemists have leveraged the unique capabilities of biological catalysts for small-molecule production, metabolic engineers have not likewise integrated reactions from organic synthesis with the metabolism of living organisms. Reported herein is a method for alkene hydrogenation which utilizes a palladium catalyst and hydrogen gas generated directly by a living microorganism. This biocompatible transformation, which requires both catalyst and microbe, and can be used on a preparative scale, represents a new strategy for chemical synthesis that combines organic chemistry and metabolic engineering. Reduction to practice: A hydrogenation reaction has been developed that employs hydrogen generated in situ by a microorganism and a biocompatible palladium catalyst to reduce alkenes on a synthetically useful scale. This type of transformation, which directly combines tools from organic chemistry with the metabolism of a living organism for small-molecule production, represents a new strategy for chemical synthesis.

AMINE DERIVATIVE

The present invention provides a compound represented by the formula wherein Ar1 is a cyclic group optionally having substituent(s); R is a hydrogen atom, an optionally halogenated C1-6 alkyl, a phenyl optionally having substituent(s

Thiazole derivative

A thiazole compound of the formula: STR1 wherein T is lower alkylene; u is 0 or 1; R1 and R2 are the same or different and are each H, or lower alkyl, etc.; R3 is STR2 R4 is H or lower alkanoyloxy-lower alkyl, which shows inhibitory activity on protein kinase C (PKC, Ca2+ /phospholipid-depending serine/threonine protein phosphatase), and are useful as a protein kinase C inhibitor.

SYNTHESES OF A REGIOISOMER OF N-PYRIMIDIN-5-YL)ETHYL>BENZOYL>-L-GLUTAMIC ACID (LY231514), AN ACTIVE THYMIDYLATE SYNTHASE INHIBITOR AND ANTITUMOR AGENT

Two independent routes to N-pyrimidin-6-yl)ethyl>benzoyl>-L-glutamic acid, a regioisomer of the potent TS inhibitor and antitumor agent LY231514, are described.Preliminary in vitro cell culture evaluation has show