199934-50-4Relevant academic research and scientific papers
Inhibition of human tumor growth by 2'-hydroxy- and 2'- benzoyloxycinnamaldehydes
Lee, Chang Woo,Hong, Dong Ho,Han, Sang Bae,Park, Se Hyung,Kim, Hyae Kyeong,Kwon, Byoung-Mog,Kim, Hwan Mook
, p. 263 - 266 (1999)
2'-Hydroxycinnamaldehyde (HCA) was isolated from Cinnamomum cassia Blume (Lauraceae) and 2'-benzoyloxycinnamaldehyde (BCA) was prepared by the reaction of HCA and benzoyl chloride. HCA and BCA strongly inhibited in vitro growth of 29 kinds of human cancer
Modular synthesis of (E)-cinnamaldehydes directly from allylarenes via a metal-free DDQ-mediated oxidative process
Xu, Ting-Ting,Jiang, Tao-Shan,Han, Xiao-Lan,Xu, Yuan-Hong,Qiao, Jin-Ping
, p. 5350 - 5358 (2018/08/03)
An efficient synthesis of (E)-cinnamaldehydes by a metal-free DDQ-mediated oxidative transformation of allylarenes was developed. The protocol provides a practical method to prepare diverse (E)-cinnamaldehydes with broad functional group tolerance in good to excellent yields, including easy access to natural products randainal and geranyloxy sinapyl aldehyde from plant extracts. Finally, the mechanism of a single-electron transfer process was proposed.
Composition for preventing cancer comprising 2'-benzoyl-oxycinnamaldehyde
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Page/Page column 4, (2008/06/13)
Disclosed is a composition for preventing cancer comprising a compound represented by Chemical Formula 1, 2′-benzoyloxycinnamaldehyde (BCA). BCA has the effects of delaying tumor incidence and increasing immune cells in a transgenic mouse overexpressing H-ras oncogene playing a critical role in tumor cell growth. Thus, BCA is useful as a cancer preventive drug.
COMPOSITION FOR PREVENTING CANCER COMPRISING 2'-BENZOYL-OXYCINNAMALDEHYDE
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Page/Page column 11, (2008/06/13)
Disclosed is a composition for preventing cancer comprising a compound represented by Chemical Formula 1, 2??-benzoyloxycinnamaldehyde (BCA). BCA has the effects of delaying tumor incidence and increasing immune cells in a transgenic mouse overexpressing H-ras oncogene playing a critical role in tumor cell growth. Thus, BCA is useful as a cancer preventive drug.
Cinnamaldehydes inhibit cyclin dependent kinase 4/cyclin D1
Jeong, Ha-Won,Kim, Mi-Ran,Son, Kwang-Hee,Young Han, Mi,Ha, Ji-Hong,Garnier, Matthieu,Meijer, Laurent,Kwon, Byoung-Mog
, p. 1819 - 1822 (2007/10/03)
A series of cinnamaldehydes was synthesized for the study of inhibitory activity against cyclin dependent kinases (CDKs). A couple of compounds selectively inhibited cyclin D1-CDK4 with an IC50 value of 7-18 μM. (C) 2000 Elsevier Science Ltd. All rights reserved.
