199938-73-3

Upstream product

• 3601-89-6 Hoffer's chlorosugar 
• 149765-16-2 N-(4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-2-yl)-2,2-dimethyl-propionamide 
• 149765-15-1 N-(4-chloro-7H-pyrrolo[2,3-d]pyrimidin-2-yl)-2,2-dimethyl-propionamide 
• 104291-20-5 (2R,3S,5R)-5-(2-amino-4-chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2-(((4-methylbenzoyl)oxy)methyl)tetrahydrofuran-3-yl 4-methylbenzoate 
• 3282-30-2 pivaloyl chloride 
• 84955-31-7 4-chloro-7H-pyrrolo[2,3-d]pyrimidin-2-amine 
• 4330-21-6 2-deoxy-3,5-di-O-p-toluoyl-α-D-erythro-pentofuranosyl chloride 

Downstream Products

• 213823-27-9 C₄₉H₄₃N₅O₇ 
• 213823-23-5 C₄₆H₄₀IN₅O₇ 
• 213823-33-7 N-[7-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-5-cyano-2-(2,2-dimethyl-propionylamino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-2,2-dimethyl-propionamide 
• 213823-30-4 C₃₈H₄₂N₆O₇ 
• 199938-84-6 C₂₈H₂₅N₅O₅ 
• 199938-77-7 C₂₅H₂₂IN₅O₅ 

Relevant academic research and scientific papers

Nucleoside heterocycle that binds to both thymidine and cytidine

This application discloses nucleoside analogs that when incorporated into a oligonucleotide, forms a nucleobase pair with either thymidine or cytidine that are present in a complementary strand at the paired position. These analogs are called “purine bive

REAGENTS FOR REVERSIBLY TERMINATING PRIMER EXTENSION

This invention relates to the field of nucleic acid chemistry, more specifically to the field of compositions of matter that comprise triphosphates of modified 2'-deoxynucleosides and oligonucleotides that are formed when these are appended to the 3'-end of a primer, wherein said modifications comprise NH2 moiety attached to their 3'-hydroxyl group and a fluorescent species in a form of a tag affixed to the nucleobase via a linker that can be cleaved. Such compositions and their associated processes enable and improve the sequencing of oligonucleotides using a strategy of cyclic reversible termination, as outlined in US Patent 6,664,079. Most specifically, the invention concerns compositions of matter that are 5'-triphosphates of ribo- and 2'- deoxyribonucleosides carrying detectable tags and oligonucleotides that might be derived from them. The invention also concerns processes wherein a DNA polymerase, RNA polymerase, or reverse transcriptase synthesizes said oligonucleotides via addition of said triphosphates to a primer.

Regioselective syntheses of 7-halogenated 7-deazapurine nucleosides related to 2-amino-7-deaza-2′-deoxyadenosine and 7-deaza-2′- deoxyisoguanosine

The syntheses of 7-halogenated derivatives 3b-e of 2-amino-7-deaza- 2′-deoxyadenosine as well as 7-bromo and 7-chloro-7-deaza-2′- deoxyisoguanosines 4b-c are described. Nucleobase anion glycosylation was employed for the convergent nucleoside synthesis. T

Positioning of functionalities in a heteroduplex major groove: Synthesis of 7-deaza-2-amino-2'-deoxyadenosines

We have synthesized the 7-iodo-, 7-cyano- and 7-propynyl-7-deaza-2- amino-2'-deoxyadenosines and incorporated each into several oligonucleotide (ODN) sequences. These oligonucleotides exhibit enhanced binding affinities to RNA complements relative to unmo