19997-22-9

Basic information

• Product Name: spiro[(6,6-dimethyl-4-oxo-3-phenyl-2,3,4,5,6,7-hexahydrobenzofuran)-2,2'-(5,5-dimethylcyclohexane-1,3-dione)]
• Synonyms: spiro[(6,6-dimethyl-4-oxo-3-phenyl-2,3,4,5,6,7-hexahydrobenzofuran)-2,2'-(5,5-dimethylcyclohexane-1,3-dione)]
• CAS NO: 19997-22-9
• Molecular Weight: 366.457
• Mol File: 19997-22-9.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: spiro[(6,6-dimethyl-4-oxo-3-phenyl-2,3,4,5,6,7-hexahydrobenzofuran)-2,2'-(5,5-dimethylcyclohexane-1,3-dione)](CAS DataBase Reference)
• NIST Chemistry Reference: spiro[(6,6-dimethyl-4-oxo-3-phenyl-2,3,4,5,6,7-hexahydrobenzofuran)-2,2'-(5,5-dimethylcyclohexane-1,3-dione)](19997-22-9)
• EPA Substance Registry System: spiro[(6,6-dimethyl-4-oxo-3-phenyl-2,3,4,5,6,7-hexahydrobenzofuran)-2,2'-(5,5-dimethylcyclohexane-1,3-dione)](19997-22-9)

Safety Data

• Hazardous Substances Data: 19997-22-9(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 7600-00-2 bis(2-hydroxy-4,4-dimethyl-6-oxo-1-cyclohexenyl)phenylmethane 
• 126-81-8 dimedone 
• 105071-90-7 triphenylbismuthonio-4,4-dimethyl-2,6-dioxocyclohexane-1-ide 

Relevant articles and documents

Synthesis of Dihydrospiro Furo[2,3- c ]pyrazoles Promoted by Hypervalent Iodine in Water

A simple, green protocol has been accomplished for the synthesis of dihydrospirofuro[2,3- c ]pyrazoles in aqueous medium involving pyrazolone and aldehydes in a one-pot reaction promoted by bis(acetoxy)iodobenzene (BAIB) at ambient temperature. The protocol presented herein describes a new transformation where two molecules of pyrazolone react with an aldehyde in a Knoevenagel condensation followed by a Michael addition, and the resulting dienol was rearranged to the title compound. High compatibility, easy work-up, and excellent yields are the advantages of this protocol.

Synthesis of Spiro-dihydrofuran in the Presence of a Novel and Reusable Nanocatalyst Cu (II)-Glycerol/MCM-41

The use of supported Cu complex on mesoporous as a novel, efficient, heterogeneous, reusable and green catalyst for the synthesis of spiro-dihydrofuran derivatives is reported. This methodology is effective for the reaction of dimedone with a wide range of aldehyde in the presence of BrCN and triethylamine. The structure of catalyst was characterized by different techniques such as EDX, SEM, TGA, ICP-OES, XRD, TEM, FT-IR, and BET. The recycled nanocatalyst was used at least five times with no significant loss of its activity.

Selective formation of spiro dihydrofurans from one-pot reaction of dimedone with BrCN and aldehydes in the presence of Et3N

Reaction of 5,5-dimethylcyclohexane-1,3-dione (dimedone), aldehydes and cyanogen bromide in the presence of triethylamine leads to the selective formation of spiro dihydrofurans in moderate to good yields at room temperature.