19997-22-9

Upstream product

• 100-52-7 benzaldehyde 
• 7600-00-2 bis(2-hydroxy-4,4-dimethyl-6-oxo-1-cyclohexenyl)phenylmethane 
• 126-81-8 dimedone 
• 105071-90-7 triphenylbismuthonio-4,4-dimethyl-2,6-dioxocyclohexane-1-ide 

Relevant academic research and scientific papers

Synthesis of Dihydrospiro Furo[2,3- c ]pyrazoles Promoted by Hypervalent Iodine in Water

A simple, green protocol has been accomplished for the synthesis of dihydrospirofuro[2,3- c ]pyrazoles in aqueous medium involving pyrazolone and aldehydes in a one-pot reaction promoted by bis(acetoxy)iodobenzene (BAIB) at ambient temperature. The protocol presented herein describes a new transformation where two molecules of pyrazolone react with an aldehyde in a Knoevenagel condensation followed by a Michael addition, and the resulting dienol was rearranged to the title compound. High compatibility, easy work-up, and excellent yields are the advantages of this protocol.

Selective synthesis of spiro and dispiro compounds using Mn(III)-based oxidation of tetracarbonyl compounds

The Mn(III)-based oxidation of methylenebis(cyclohexanedione)s and methylenebis(piperidinedione)s as a tetracarbonyl compound was investigated under various conditions, selectively producing spiro dihydrofurans and dispiro cyclopropanes depending on the solvent. The mechanism for the formation of the spiro dihydrofurans and dispiro cyclopropanes was discussed. In addition, a simple synthesis of a new type of alkaloid, 3,4,6,7,8,10-hexahydro-1H-pyrano[3,2-c:5,6-c’]dipyridine-1,9(2H)-diones, was demonstrated.

Synthesis of Spiro-dihydrofuran in the Presence of a Novel and Reusable Nanocatalyst Cu (II)-Glycerol/MCM-41

The use of supported Cu complex on mesoporous as a novel, efficient, heterogeneous, reusable and green catalyst for the synthesis of spiro-dihydrofuran derivatives is reported. This methodology is effective for the reaction of dimedone with a wide range of aldehyde in the presence of BrCN and triethylamine. The structure of catalyst was characterized by different techniques such as EDX, SEM, TGA, ICP-OES, XRD, TEM, FT-IR, and BET. The recycled nanocatalyst was used at least five times with no significant loss of its activity.

A pseudo multi-component electrochemical synthesis of spiro dihydrofuran derivatives

An electrochemical strategy to the assembly of tricyclic spiro dihydrofuran scaffold via the reaction of aryl aldehyde and dimedone has been developed successfully. This protocol has the advantages of high yields, wide application scope and an environmental benign procedure compared with the reported methods.

Selective formation of spiro dihydrofurans from one-pot reaction of dimedone with BrCN and aldehydes in the presence of Et3N

Reaction of 5,5-dimethylcyclohexane-1,3-dione (dimedone), aldehydes and cyanogen bromide in the presence of triethylamine leads to the selective formation of spiro dihydrofurans in moderate to good yields at room temperature.

Single-pot synthesis of spiroannulated dihydrofurans by iodine-ammonium acetate-mediated reaction of dimedone with aldehydes

Iodine-ammonium acetate-mediated annealation of dimedone with aldehydes led to facile formation of spirodihydrofuran in good yields through tandem Knoevenagel-Michael iodonation and cyclodehydroiodonation reactions in a single pot.

Reaction of Stabilized Bismuthonium Ylides with Aldehydes. A Novel Reaction Mode of the Heaviest Group V Element Ylide

Stabilized bismuthonium ylides, triphenylbismuthonio-4,4-dimethyl-2,6-dioxocyclohexane-1-ide and triphenylbismuthonio-4,4-dimethyl-2,6-dioxo-3,5-dioxan-1-ide, react with aldehydes to afford three types of products; tetraacylcyclopropanes, dihydrofurans, and α,β-unsaturated carbonyl compounds, the relative importance of these depending greatly on the ylides, aldehydes, and reaction conditions employed.