199982-01-9Relevant articles and documents
Electron transfer reactions of photochemically generated ruthenium(III)-polypyridyl complexes with methionines
Thiruppathi, Dharmaraj,Karuppasamy, Periyakaruppan,Ganesan, Muniyandi,Sivasubramanian, Veluchamy Kamaraj,Rajendran, Thangamuthu,Rajagopal, Seenivasan
, p. 606 - 618 (2014/12/09)
The oxidation of methionine (Met) plays an important role during biological conditions of oxidative stress as well as for protein stability. Ruthenium(III)-polypyridyl complexes, [Ru(NN)3]3+, generated from the photochemical oxidation of the corresponding Ru(II) complexes with molecular oxygen, undergo a facile electron transfer reaction with Met to form methionine sulfoxide (MetO) as the final product. Interaction of [Ru(NN)3]3+ with methionine leads to the formation of >S+? and (>S∴S+ species as intermediates during the course of the reaction. The interesting spectral, kinetic, and mechanistic study of the electron transfer reaction of four substituted methionines with six [Ru(NN)3]3+ ions carried out in aqueous CH3CN (1:1, v/v) by a spectrophotometric technique shows that the reaction rate is susceptible to the nature of the ligand in [Ru(NN)3]3+ and the structure of methionine. The rate constants calculated by the application of Marcus semiclassical theory to these redox reactions are in close agreement with the experimental values.
