2000-55-7

Usage

Uses

Used in Agriculture:
Urea, N-phenyl-N'-3-pyridinylis used as a pesticide and insect repellent for protecting crops from pests and insects. It works by disrupting the nervous system of the pests, ultimately leading to their death. This helps to ensure a healthy and abundant crop yield.
Used in Pharmaceutical Industry:
Urea, N-phenyl-N'-3-pyridinylis considered a potential candidate for the treatment of various neurological disorders. Its ability to modulate the activity of certain neurotransmitters makes it a promising agent for managing conditions such as Alzheimer's disease, Parkinson's disease, and other neurodegenerative disorders.
However, the use of Urea, N-phenyl-N'-3-pyridinylas a pesticide and insect repellent raises concerns about its potential impact on human health and the environment. Therefore, its usage should be carefully regulated and monitored to minimize any adverse effects. Further research is also needed to fully understand the compound's mechanism of action and to develop safer and more effective formulations for agricultural and medical applications.

Upstream product

• 462-08-8 pyridin-3-ylamine 
• 103-71-9 phenyl isocyanate 
• 4013-72-3 nicotinoyl azide 
• 62-53-3 aniline 
• 15268-31-2 3-Pyridyl isocyanate 
• 626-60-8 3-Chloropyridine 
• 64-10-8 phenyl carbamate 
• 13114-65-3 1-(pyridin-3-yl)urea 
• 19226-36-9 3-phenyl-5H-1,4,2-dioxazol-5-one 
• 55-21-0 benzamide 
• 20260-53-1 pyridine-3-carbonyl chloride hydrochloride 
• 1692-25-7 3-pyridylboronic acid 
• 626-55-1 3-Bromopyridine 
• 1120-90-7 3-iodopyridine 

Downstream Products

• 1430116-30-5 C₂₇H₃₃CuN₇O₉S 
• 862886-18-8 [(1-phenyl-3-pyridine-3-yl-urea)2Ag]PF₆ 

Relevant academic research and scientific papers

Synthesis of unsymmetrical urea from aryl- or pyridyl carboxamides and aminopyridines using PhI(OAc)2via in situformation of aryl- or pyridyl isocyanates

A tandem synthesis of unsymmetrical ureas (N-aryl-N′-pyridylurea andN,N′-bipyridylurea) from aryl- or pyridyl carboxamides and aminopyridinesviaHofmann rearrangement has been reported. In particular, benzamides, picolinamide, nicotinamide, and isonicotinamide generate reactive intermediate isocyanates,in situ, in the presence of PhI(OAc)2, which upon further reaction with aminopyridines form urea derivatives. As the formation of pyridylisocyanates from their corresponding carboxamidesviaHofmann rearrangement remained unexplored previously, attempts have been made to trap the isocyanates. While the three pyridylisocyanates were trapped as their corresponding carbamates, 3-pyridylisocyanate was isolated and characterized. Unlike closely related previous methods reported for urea synthesis, the current method avoids direct use of isocyanates or eliminates the use of toxic phosgene for thein situgeneration of isocyanates.

Synthesis and characterization of N,N,N-trimethyl-O-(ureidopyridinium)acetyl chitosan derivatives with antioxidant and antifungal activities

Chitosan is an active biopolymer, and the combination of it with other active groups can be a valuable method to improve the potential application of the resultant derivatives in food, cosmetics, packaging materials, and other industries. In this paper, a series of N,N,N-trimethyl-O-(ureidopyridinium)acetyl chitosan derivatives were synthesized. The combination of chitosan with ureidopyridinium group and quaternary ammonium group made it achieve developed water solubility and biological properties. The structures of chitosan and chitosan derivatives were confirmed by FTIR,1H NMR spectra, and elemental analysis. The prepared chitosan derivatives were evaluated for antioxidant property by 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging ability, hydroxyl radical scavenging ability, and superoxide radical scavenging ability. The results revealed that the synthesized chitosan derivatives exhibited improved antioxidant activity compared with chitosan. The chitosan derivatives were also investigated for antifungal activity against Phomopsis asparagus as well as Botrytis cinerea, and they showed a significant inhibitory effect on the selected phytopathogen. Meanwhile, CCK-8 assay was used to test the cytotoxicity of chitosan derivatives, and the results showed that most derivatives had low toxicity. These data suggested to develop analogs of chitosan derivatives containing ureidopyridinium group and quaternary ammonium group, which will provide a new kind of promising biomaterials having decreased cytotoxicity as well as excellent antioxidant and antimicrobial activity.

Synthetic method and application of urea compound

The invention relates to a synthetic method of a urea compound, comprising the following steps: adding substituted oxazolone and sodium acetate into a methanol solution, and adding substituted amine under the stirring condition, reacting and carrying out column chromatography to obtain the urea compound. The defect that dangerous compounds need to be used during existing synthetic process is overcome, and a one-pot method is adopted to replace an existing reaction with low yield. The method of the invention has mild reaction condition, the operation is simple, raw materials are easily available, and the substrate can be converted into various other useful molecules. The compound has strong practicality, and can be applied to synthesis of the pesticide daimuron, dieresis long and the anti-cancer drug Sorafenib. The invention relates to a green and environmentally-friendly unsymmetrical urea compound synthesis method with simple process and low cost.

ORGANIC MOLECULES FOR TERAHERTZ TAGGING APPLICATIONS

The present invention discloses substituted heterocyclic compounds and /or aromatic compounds containing amide and/or urea groups exhibiting resonance in the range of 0.1- 10 THz. The invention also discloses binary molecular complexes based on the substituted heterocyclic compounds and/or aromatic compounds containing amide and/or urea groups of the present invention. The compounds and binary molecular complexes of the present invention have varying molecular mass and hydrogen bond strengths demonstrating several resonances below 10 THz. The compounds and binary molecular complexes of the present invention are customizable for various applications, such as authentication of a product.

Studying fluorous interactions in a series of coordination compounds derived from mono-pyridyl ligands equipped with hydrogen bonding functionality: Exploiting anion...πF interaction in separating ClO 4- anion from a competing mixture of anions

A series of coordination compounds (both coordination complexes (CCs) and coordination polymers (CPs)) viz. [Cu(L1)4·(SO 4)·(DMSO)]CC1, [(H2O)2(DMSO)Cd(L1) 2(μ2SO4)(Cd(L1)2·(SO 4)·(DMSO)·(H2O)] CC2, [Cu(L2) 2(H2O)·(Cl)2] CC3, [Cu(L2) 2(μ-SO4)(H2O)]∝CP1, [{Cu(L2)4(μ-SiF6)}·3H2O] ∝CP2, [{Cu(L3)4(ClO4)}·ClO 4·H2O]·CC4, [{Cu(L3)4(H 2O)}·H2O·2BF4] CC5, [{(Cl)Cu(L3)4(μ-Cl)Cu(L3)4}·Cl·H 2O] CC6, [{Cu2(L3)4(μ-Cl) 2·(Cl)2}·H2O] CC7, [Cu(L3) 2(Cl)2] CC8, and [{Cu(L4)4·(H 2O)2}·SO4·5H2O] CC9 derived from ligands equipped with pyridyl and pentafluorophenyl/phenyl moieties along with hydrogen bonding backbone (amide/urea) with CuII/Cd II metal centers have been synthesized and characterized by single crystal X-ray diffraction (SXRD). Their various fluorous interactions along with hydrogen bonding have been investigated. The results show that almost all the coordination compounds except CC9 studied herein display various fluorous interactions; in one such example i.e. in CC4, anion-πF along with other supramolecular interactions (F...F, C-H...F) shapes the supramolecular assembly, which is exploited to separate environmentally relevant perchlorate anion from a competing mixture of anions viz. SO4 2-, NO3-, ClO4-, BF 4-, Cl- by following in situ synthesis of the corresponding coordination compound.

Selective recognition of sulphate in a Cu(ii) assisted 1D polymer of a simple pentafluorophenyl substituted pyridyl-urea via second sphere coordination

A pentafluorophenyl (-C6F5) substituted 3-pyridyl urea, L1, is explored extensively to demonstrate SO4 2- binding exclusively via second sphere coordination in the cavity of a 1D polymeric self-assemb

Cu(acac)2-catalyzed N-arylations of phenylurea with aryl boronic acid

Cu(acac)2 activates aryl boronic acids for the reaction with NH2-phenylurea without additional ligand and heating. The procedure is simple, general, ligand-free, milder than the palladium-catalyzed arylation, and avoids the use of toxic phosphine ligands. Copyright Taylor & Francis Group, LLC.

An efficient method for the N-arylation of phenylurea via copper catalyzed amidation

The coupling reaction of phenylurea with different functionalized aryl halides in the presence of air stable CuI, N,N-dimethylethylenediamine as a ligand, and K3PO4 as a base gives symmetrical and unsymmetrical diarylureas in relatively high yields. This method is milder than the palladium catalyzed arylation and avoids the use of toxic phosphine ligands.

Microwave assisted, solvent- and ligand-free copper catalyzed N-arylation of phenylurea with aryl halides

An inexpensive and efficient catalyst system has been developed for the N-arylation of phenylurea including a variety of aryl halides. This simple protocol uses Cu2O as the catalyst, microwave assisted, solvent- and ligand-free, K3PO4.H2O as the base.

Microwave assisted, ligand free, copper catalyzed reaction of aryl halides with phenyl urea

The ligand free coupling reaction of phenyl urea with different functionalized aryl halides in the presence of air stable Cu2O and t-BuOK as a base gives symmetrical and unsymmetrical diarylureas in relatively high yields. This method is milder than the palladium catalyzed arylation and avoids the use of toxic phosphine ligand.