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200006-08-2

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  • 2-[[(3r)-3-(4-fluorophenyl)-3-(4-phenylphenoxy)propyl]-methylamino]acetic Acid,hydrochloride

    Cas No: 200006-08-2

  • USD $ 18.0-20.0 / Kilogram

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  • 10000 Metric Ton/Year

  • EAST CHEMSOURCES LIMITED
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  • 2-[[(3r)-3-(4-fluorophenyl)-3-(4-phenylphenoxy)propyl]-methylamino]acetic Acid,hydrochloride

    Cas No: 200006-08-2

  • USD $ 1.5-1.5 / Metric Ton

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  • 1000 Metric Ton/Day

  • KAISA GROUP INC
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  • 2-[[(3r)-3-(4-fluorophenyl)-3-(4-phenylphenoxy)propyl]-methylamino]acetic Acid,hydrochloride

    Cas No: 200006-08-2

  • USD $ 1.0-1.0 / Metric Ton

  • 1 Metric Ton

  • 100 Metric Ton/Day

  • Bluecrystal chem-union
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200006-08-2 Usage

Uses

Different sources of media describe the Uses of 200006-08-2 differently. You can refer to the following data:
1. ALX 5407 Hydrochloride can be used in the preparation of amino acid derivatives as pharmaceuticals for treatment of neurological and neuropsychiatric disorders.
2. ALX 5407 hydrochloride has been used as a glycine transporter (GlyT1) inhibitor to test its effect on inhibitory postsynaptic current and N-methyl-D-aspartate receptor (NMDA)-mediated excitatory postsynaptic currents (EPSCs). It has also been used as a GlyT1 inhibitor to treat developmentally diminished NMDA receptor (Grin1D481N) mice to test its effect on the glycine site function.

Biochem/physiol Actions

ALX-5407 hydrochloride (NFPS hydrochloride) is a selective irreversible inhibitor of the glycine transporter GlyT1 with IC50 values of 3 nM for GlyT1 compared to 100 μM for GlyT2. ALX-5407 hydrochloride showed no activity at the inhibitory glycine receptor or glycine site of the NMDA receptor (IC50 > 100 mM).

references

[1]. atkinson bn, bell sc, de vivo m, et al. alx 5407: a potent, selective inhibitor of the hglyt1 glycine transporter. mol pharmacol, 2001, 60(6):1414-20.

Check Digit Verification of cas no

The CAS Registry Mumber 200006-08-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,0,0,0,0 and 6 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 200006-08:
(8*2)+(7*0)+(6*0)+(5*0)+(4*0)+(3*6)+(2*0)+(1*8)=42
42 % 10 = 2
So 200006-08-2 is a valid CAS Registry Number.

200006-08-2 Well-known Company Product Price

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  • Sigma

  • (SML0897)  ALX 5407 hydrochloride  ≥98% (HPLC)

  • 200006-08-2

  • SML0897-5MG

  • 1,107.99CNY

  • Detail
  • Sigma

  • (SML0897)  ALX 5407 hydrochloride  ≥98% (HPLC)

  • 200006-08-2

  • SML0897-25MG

  • 4,469.40CNY

  • Detail

200006-08-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-[[(3R)-3-(4-fluorophenyl)-3-(4-phenylphenoxy)propyl]-methylamino]acetic acid,hydrochloride

1.2 Other means of identification

Product number -
Other names N-[(3R)-3-([1,1'-Biphenyl]-4-yloxy)-3-(4-fluorophenyl)propyl]-N-methylglycine Hydrochloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:200006-08-2 SDS

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