200006-08-2 Usage
Uses
Different sources of media describe the Uses of 200006-08-2 differently. You can refer to the following data:
1. ALX 5407 Hydrochloride can be used in the preparation of amino acid derivatives as pharmaceuticals for treatment of neurological and neuropsychiatric disorders.
2. ALX 5407 hydrochloride has been used as a glycine transporter (GlyT1) inhibitor to test its effect on inhibitory postsynaptic current and N-methyl-D-aspartate receptor (NMDA)-mediated excitatory postsynaptic currents (EPSCs). It has also been used as a GlyT1 inhibitor to treat developmentally diminished NMDA receptor (Grin1D481N) mice to test its effect on the glycine site function.
Biochem/physiol Actions
ALX-5407 hydrochloride (NFPS hydrochloride) is a selective irreversible inhibitor of the glycine transporter GlyT1 with IC50 values of 3 nM for GlyT1 compared to 100 μM for GlyT2. ALX-5407 hydrochloride showed no activity at the inhibitory glycine receptor or glycine site of the NMDA receptor (IC50 > 100 mM).
references
[1]. atkinson bn, bell sc, de vivo m, et al. alx 5407: a potent, selective inhibitor of the hglyt1 glycine transporter. mol pharmacol, 2001, 60(6):1414-20.
Check Digit Verification of cas no
The CAS Registry Mumber 200006-08-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,0,0,0,0 and 6 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 200006-08:
(8*2)+(7*0)+(6*0)+(5*0)+(4*0)+(3*6)+(2*0)+(1*8)=42
42 % 10 = 2
So 200006-08-2 is a valid CAS Registry Number.