20004-62-0 Usage
Uses
Different sources of media describe the Uses of 20004-62-0 differently. You can refer to the following data:
1. Resistomycin is a tetrahydroxyantrone has been independently isolated by several groups and reported to have a broad range of biological activities. Resistomycin is active against bacteria, including mycobacteria, and viruses. Resistomycin induces apoptosis and inhibits RNA polymerase.
2. Resistomycin is a tetrahydroxyanthrone that has been independently isolated by several groups and reported to have a broad range of biological activities. Resistomycin is active against bacteria, including mycobacteria, and viruses. Resistomycin induces apoptosis and inhibits RNA polymerase.
3. Resistomycin is an antibiotic RNA polymerase inhibitor and apoptosis inducer.
Biological Activity
resistomycin is a natural antibiotic.resistomycin is a natural antibiotic produced by several actinobacteriae, such as streptomyces.
in vitro
resistomycin, a tetrahydroxyanthrone derivative, was isolated from the culture broth of streptomyces sulphureus and a similar polyphenolic dianthraquinone, hypericin, was isolated from an extract of hypericum perforatum l. as modulators for apoptosis. in human megakaryoblastic leukemia cmk-7 cells, resistomycin could inhibit apoptosis induced by actinomycin d (ad) with or without acceleration by colcemid (cl), ic50 for inhibition against ad-induced apoptosis was about 0.5 μm and ic50 for inhibition against ad plus cl-induced apoptosis was about 1 μm. cl alone induced weak apoptosis in cells, which could be enhanced by resistomycin. moreover, it was found that both hypericin and resistomycin were able to scavenge superoxide anion radicals at the same rate as luteolin. in addition, pkc in cmk-7 cells could be inhibited by hypericin and luteolin, but not obviously inhibited by resistomycin [1].
references
[1] shiono, y. ,shiono, n.,seo, s., et al. effects of polyphenolic anthrone derivatives, resistomycin and hypercin, on apoptosis in human megakaryoblastic leukemia cmk-7 cell line. z. naturforsch. c. 57(9-10), 923-929 (2002).
Check Digit Verification of cas no
The CAS Registry Mumber 20004-62-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,0,0,0 and 4 respectively; the second part has 2 digits, 6 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 20004-62:
(7*2)+(6*0)+(5*0)+(4*0)+(3*4)+(2*6)+(1*2)=40
40 % 10 = 0
So 20004-62-0 is a valid CAS Registry Number.
