20005-91-8

Upstream product

• 93-55-0 1-phenyl-propan-1-one 
• 1655-07-8 ethyl 2-oxocyclohexane carboxylate 
• 3506-36-3 3-dimethylaminopropiophenone 
• 768-03-6 Phenyl vinyl ketone 

Relevant academic research and scientific papers

Cu-catalyzed sequential dehydrogenation-conjugate addition for β-functionalization of saturated ketones: Scope and mechanism

The first copper-catalyzed direct β-functionalization of saturated ketones is reported. This protocol enables diverse ketones to couple with a wide range of nitrogen, oxygen and carbon nucleophiles in generally good yields under operationally simple conditions. The detailed mechanistic studies including kinetic studies, KIE measurements, identification of reaction intermediates, EPR and UV-visible experiments were conducted, which reveal that this reaction proceeds via a novel radical-based dehydrogenation to enone and subsequent conjugate addition sequence.

Indium(III) chloride catalyzed conjugate addition of 1,3-dicarbonyl compounds to α,β-unsaturated ketones

Indium trichloride catalyzes efficiently the Michael reactions of 1,3-dicarbonyl compounds with α,β-unsaturated ketones to afford the corresponding Michael adducts in high yields with high selectivity.