200055-61-4

Upstream product

• 144001-87-6 (2Z,4R,5R) methyl 4-acetoxy-5-[(2S)-N-(benzoxycarbonyl)aziridin-2-yl]-5-[(tert-butyldimethylsilyl)oxy]-2-[N-(methoxycarbonyl)amino]-2-pentenoate 
• 144001-86-5 Methyl 2-(dimethoxyphosphinyl)-2-ethanoate 
• 144001-85-4 (S)-2-[(1R,2S)-2-Acetoxy-1-(tert-butyl-dimethyl-silanyloxy)-3-oxo-propyl]-aziridine-1-carboxylic acid benzyl ester 
• 3006-58-4 2-carbobenzyloxyamino-2-deoxy-D-glucopyranose 
• 501-53-1 benzyl chloroformate 
• 144001-84-3 (S)-2-[(1R,2R)-2-Acetoxy-1-(tert-butyl-dimethyl-silanyloxy)-but-3-enyl]-aziridine-1-carboxylic acid benzyl ester 
• 144001-93-4 Acetic acid (1R,2R,3R)-3-benzyloxycarbonylamino-2-(tert-butyl-dimethyl-silanyloxy)-4-oxo-1-vinyl-butyl ester 
• 144001-83-2 Acetic acid (1R,2R,3S)-3-benzyloxycarbonylamino-2-(tert-butyl-dimethyl-silanyloxy)-4-hydroxy-1-vinyl-butyl ester 
• 4704-15-8 ((2S,3R,4R,5S,6R)-4,5-Dihydroxy-6-hydroxymethyl-2-methoxy-tetrahydro-pyran-3-yl)-carbamic acid benzyl ester 
• 141438-52-0 [(2R,4aR,6S,7R,8R,8aS)-8-Hydroxy-6-methoxy-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl]-carbamic acid benzyl ester 
• 144001-81-0 [(2R,4aR,6S,7R,8R,8aR)-8-(tert-Butyl-dimethyl-silanyloxy)-6-methoxy-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl]-carbamic acid benzyl ester 
• 144001-82-1 Acetic acid (2S,3R,4R,5R,6S)-5-benzyloxycarbonylamino-4-(tert-butyl-dimethyl-silanyloxy)-2-iodomethyl-6-methoxy-tetrahydro-pyran-3-yl ester 
• 144001-92-3 [(2S,3R,4R,5R,6S)-4-(tert-Butyl-dimethyl-silanyloxy)-5-hydroxy-6-iodomethyl-2-methoxy-tetrahydro-pyran-3-yl]-carbamic acid benzyl ester 

Downstream Products

• 144070-33-7 (2Z,4R,5R) methyl 4-acetoxy-5-[(2S)-N-(benzoxycarbonyl)aziridin-2-yl]-3-bromo-5-[(tert-butyldimethylsilyl)oxy]-2-[N-(methoxycarbonyl)amino]-2-pentenoate 
• 144001-89-8 (2E,4R,5R) methyl 4-acetoxy-5-[(2S)-N-(benzoxycarbonyl)aziridin-2-yl]-3-bromo-5-[(tert-butyldimethylsilyl)oxy]-2-[N-(methoxycarbonyl)amino]-2-pentenoate 

Relevant academic research and scientific papers

The development of strategies for construction of the aziridine core of the antitumor agents azinomycins A and B

The synthesis of the C6-C13 aziridino[1,2a]pyrrolidine core substructure of the antitumor agents azinomycins A (1a) and B (1b) is described. Key synthetic steps included Wadsworth-Horner-Emmons olefination for formation of the C7-C8 double bond, an E-sele

Synthesis of the Aziridinopyrrolidine Substructure of the Antitumor Agents Azinomycin A and B

A stereoselective synthesis of the central aziridinopyrrolidine substructure (19) of the antitumor agents azinomycin A and B is reported and featured as the key step an intramolecular Michael addition-elimination reaction between the aziridine and