20006-85-3Relevant articles and documents
Freeman,P.K. et al.
, p. 1448 - 1453 (1968)
Growth factor receptor inhibitors and use thereof
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Paragraph 0230; 0232-0234, (2018/04/21)
Belonging to the chemical pharmaceutical field, the invention in particular relates to a compound shown as formula I or its pharmaceutically acceptable salt, isomer, solvate, crystal or prodrug, and pharmaceutical compositions containing the compounds, and application of the compounds or compositions in drug preparation. The compound has good growth factor receptor inhibitory activity, and can effectively reduce the incidence of tumors and prolong the life of tumor patients. (formula I).
Pd(0)-catalyzed oxy- and aminoalkynylation of olefins for the synthesis of tetrahydrofurans and pyrrolidines
Nicolai, Stefano,Waser, Jerome
supporting information; experimental part, p. 6324 - 6327 (2012/01/13)
The first Pd(0)-catalyzed intramolecular oxy- and aminoalkynylation of nonactivated olefins is reported. The reaction gives access to important tetrahydrofuran and pyrrolidine heterocycles with high diastereoselectivity. The unique synthetic potential of acetylenes is further exploited to access key building blocks for the synthesis of bioactive natural products.